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<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-11-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Changes_In_Management/2025-11-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2025-11-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2025-11-30.xsd"/><xbrli:context id="MainD"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">539268</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-07-08</xbrli:startDate><xbrli:endDate>2026-07-08</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">539268</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-07-08</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="I_ChangeInManagement1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">539268</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-07-08</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ChangeInManagementAxis"><in-capmkt:ChangeInManagementDomain>ChangeInManagementDomain1</in-capmkt:ChangeInManagementDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context 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dimension="in-capmkt:ResignationOfStatutoryAuditorAxis"><in-capmkt:ResignationOfStatutoryAuditorDomain>ResignationOfStatutoryAuditorDomain1</in-capmkt:ResignationOfStatutoryAuditorDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_ResignationOfStatutoryAuditor1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">539268</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-07-08</xbrli:startDate><xbrli:endDate>2026-07-08</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResignationOfStatutoryAuditorAxis"><in-capmkt:ResignationOfStatutoryAuditorDomain>ResignationOfStatutoryAuditorDomain1</in-capmkt:ResignationOfStatutoryAuditorDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><in-capmkt:NSESymbol contextRef="MainI">SYNGENE</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">SYNGENE INTERNATIONAL LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">539268</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE398R01022</in-capmkt:ISIN><in-capmkt:WhetherDisclosureFiledForListedEntity contextRef="MainD">false</in-capmkt:WhetherDisclosureFiledForListedEntity><in-capmkt:NameOfEntityForWhichTheDisclosureIsFiled contextRef="MainD">Syngene Scientific Solutions Limited</in-capmkt:NameOfEntityForWhichTheDisclosureIsFiled><in-capmkt:RelationshipWithTheListedEntity contextRef="MainD">Material Subsidiary</in-capmkt:RelationshipWithTheListedEntity><in-capmkt:WhetherEventOrInformationIsAnOutcomeOfBoardMeeting contextRef="MainD">false</in-capmkt:WhetherEventOrInformationIsAnOutcomeOfBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainD">2026-07-07</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainD">20:00:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:NumberOfPersonsOrEntitiesForWhomChangeIsBeingReported contextRef="MainI" unitRef="pure" decimals="0">1</in-capmkt:NumberOfPersonsOrEntitiesForWhomChangeIsBeingReported><in-capmkt:DateOfReport contextRef="MainI">2026-07-08</in-capmkt:DateOfReport><in-capmkt:TypeOfChange contextRef="D_ChangeInManagement1">Cessation</in-capmkt:TypeOfChange><in-capmkt:CategoryOfCessation contextRef="D_ChangeInManagement1">Resignation</in-capmkt:CategoryOfCessation><in-capmkt:CategoryForChange contextRef="D_ChangeInManagement1">Auditors</in-capmkt:CategoryForChange><in-capmkt:DesignationOfDesignatedPerson contextRef="D_ChangeInManagement1">Statutory Auditor</in-capmkt:DesignationOfDesignatedPerson><in-capmkt:SalutationOfDesignatedPerson contextRef="D_ChangeInManagement1">M/s.</in-capmkt:SalutationOfDesignatedPerson><in-capmkt:NameOfDesignatedPerson contextRef="I_ChangeInManagement1">B S R &amp; Co. LLP</in-capmkt:NameOfDesignatedPerson><in-capmkt:EffectiveDateOfReasonOfChange contextRef="I_ChangeInManagement1">2026-07-07</in-capmkt:EffectiveDateOfReasonOfChange><in-capmkt:WhetherInformationToBeObtainedFromTheStatutoryAuditorUponResignationAsPerSEBICircularCIRCFDCMD11142019Dated18October2019 contextRef="D_ChangeInManagement1">true</in-capmkt:WhetherInformationToBeObtainedFromTheStatutoryAuditorUponResignationAsPerSEBICircularCIRCFDCMD11142019Dated18October2019><in-capmkt:WhetherTheFurtherDisclosureForResignationOfStatutoryAuditorOrDirectorOrKMPsOrSMPOrComplianceOfficerIsToBeFiledAlongWithThisDisclosure contextRef="D_ChangeInManagement1">true</in-capmkt:WhetherTheFurtherDisclosureForResignationOfStatutoryAuditorOrDirectorOrKMPsOrSMPOrComplianceOfficerIsToBeFiledAlongWithThisDisclosure><in-capmkt:NameOfTheStatutoryAuditorOrFirm contextRef="I_ResignationOfStatutoryAuditor1">B S R &amp; Co. LLP</in-capmkt:NameOfTheStatutoryAuditorOrFirm><in-capmkt:DateOnWhichTheStatutoryAuditorWasAppointed contextRef="I_ResignationOfStatutoryAuditor1">2023-07-21</in-capmkt:DateOnWhichTheStatutoryAuditorWasAppointed><in-capmkt:DateOnWhichTheResignationLetterWasReceivedFromStatutoryAuditor contextRef="D_ResignationOfStatutoryAuditor1">2026-07-07</in-capmkt:DateOnWhichTheResignationLetterWasReceivedFromStatutoryAuditor><in-capmkt:EffectiveDateOfResignation contextRef="I_ResignationOfStatutoryAuditor1">2026-07-07</in-capmkt:EffectiveDateOfResignation><in-capmkt:DateOnWhichTheTermOfTheStatutoryAuditorWasScheduledToExpire contextRef="I_ResignationOfStatutoryAuditor1">Conclusion of 6th Annual General Meeting after the financial year ended 3 1 March 2028</in-capmkt:DateOnWhichTheTermOfTheStatutoryAuditorWasScheduledToExpire><in-capmkt:DateOfSubmissionOfLatestAuditReportOrLimitedReviewReportSubmittedPriorToResignationByTheAuditor contextRef="I_ResignationOfStatutoryAuditor1">Audit Report dated 28 April 2026</in-capmkt:DateOfSubmissionOfLatestAuditReportOrLimitedReviewReportSubmittedPriorToResignationByTheAuditor><in-capmkt:PeriodForWhichTheResigningAuditorWillIssueTheAuditReportOrLimitedReviewReportAsOnTheDateOfResignationWithReferenceAsPerSEBICircularCIRCFDCMD11142019Dated18October2019 contextRef="I_ResignationOfStatutoryAuditor1">Audit Report dated 28 April 2026</in-capmkt:PeriodForWhichTheResigningAuditorWillIssueTheAuditReportOrLimitedReviewReportAsOnTheDateOfResignationWithReferenceAsPerSEBICircularCIRCFDCMD11142019Dated18October2019><in-capmkt:DetailedReasonForResignation contextRef="I_ResignationOfStatutoryAuditor1">The management intends to align auditors with the auditors of Syngene International Limited, the holding company, due to mandatory rotation of the firm as auditors of the holding company under the Companies Act, 2013. In view of the above,the auditor would not be in a position to continue as statutory auditors of the Company for the year ended 31 March 2027.</in-capmkt:DetailedReasonForResignation><in-capmkt:EffortsMadeByTheAuditorPriorToResignation contextRef="I_ResignationOfStatutoryAuditor1">Not applicable</in-capmkt:EffortsMadeByTheAuditorPriorToResignation><in-capmkt:WhetherTheInabilityToObtainSufficientAppropriateAuditEvidenceWasDueToAManagementImposedLimitationOrCircumstancesBeyondTheControlOfTheManagement contextRef="I_ResignationOfStatutoryAuditor1">Not applicable</in-capmkt:WhetherTheInabilityToObtainSufficientAppropriateAuditEvidenceWasDueToAManagementImposedLimitationOrCircumstancesBeyondTheControlOfTheManagement><in-capmkt:WhetherTheLackOfInformationWouldHaveSignificantImpactOnTheFinancialStatementsOrResultsOfListedEntityAsWellAsMaterialSubsidiary contextRef="D_ResignationOfStatutoryAuditor1">NA</in-capmkt:WhetherTheLackOfInformationWouldHaveSignificantImpactOnTheFinancialStatementsOrResultsOfListedEntityAsWellAsMaterialSubsidiary><in-capmkt:WhetherTheAuditorHasPerformedAlternativeProceduresToObtainAppropriateEvidenceForThePurposesOfAuditOrLimitedReviewAsLaidDownInSa705Revised contextRef="D_ResignationOfStatutoryAuditor1">NA</in-capmkt:WhetherTheAuditorHasPerformedAlternativeProceduresToObtainAppropriateEvidenceForThePurposesOfAuditOrLimitedReviewAsLaidDownInSa705Revised><in-capmkt:WhetherTheLackOfInformationWasPrevalentInThePreviousReportedFinancialStatementsOrResultsAndOnWhatBasisThePreviousAuditOrLimitedReviewReportsWereIssued contextRef="D_ResignationOfStatutoryAuditor1">NA</in-capmkt:WhetherTheLackOfInformationWasPrevalentInThePreviousReportedFinancialStatementsOrResultsAndOnWhatBasisThePreviousAuditOrLimitedReviewReportsWereIssued><in-capmkt:AnyOtherFactsRelevantToTheResignation contextRef="I_ResignationOfStatutoryAuditor1">None</in-capmkt:AnyOtherFactsRelevantToTheResignation><in-capmkt:WhetherTheAuditorHasProvidedAResignationLetterAlongWithTheNecessaryDetailsAndDeclarationAsPerSEBICircularCIRCFDCMD11142019Dated18October2019 contextRef="D_ResignationOfStatutoryAuditor1">true</in-capmkt:WhetherTheAuditorHasProvidedAResignationLetterAlongWithTheNecessaryDetailsAndDeclarationAsPerSEBICircularCIRCFDCMD11142019Dated18October2019></xbrli:xbrl>
