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<!--SAIIM V1.0 (22-04-2026)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2026-03-31/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Schedule_Of_Analysts_Or_Institutional_Investors_Meeting/2026-03-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="http://www.sebi.gov.in/xbrl/Schedule_Of_Analysts_Or_Institutional_Investors_Meeting/2026-03-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2026-03-31/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2026-03-31.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">500124</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-10-24</xbrli:instant></xbrli:period></xbrli:context><in-capmkt:NSESymbol contextRef="MainI">DRREDDY</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">Dr.Reddy's Laboratories Limited</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">500124</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE089A01031</in-capmkt:ISIN><in-capmkt:TypeOfAnnouncement contextRef="MainI">New</in-capmkt:TypeOfAnnouncement><in-capmkt:PurposeOfDisclosure contextRef="MainI">Audio Recording/Video Recording</in-capmkt:PurposeOfDisclosure><in-capmkt:RemarksForWebsiteDissemination contextRef="MainI">  &lt;br /&gt; 
uploaded on the website of the Company &lt;br /&gt; 
 &lt;br /&gt; 
Audio file : https://www.drreddys.com/cms/sites/default/files/2026-10/GMT20261023-140009_Recording.mp3 &lt;br /&gt; 
 &lt;br /&gt; 
  &lt;br /&gt; 
Video file: https://players.brightcove.net/6416033764001/tBVDE8HXN_default/index.html?videoId=6407301667112 &lt;br /&gt; 
</in-capmkt:RemarksForWebsiteDissemination><in-capmkt:DateOfReport contextRef="MainI">2026-10-24</in-capmkt:DateOfReport><in-capmkt:TypeOfAudioRecordingOrVideoRecording contextRef="MainI">Audio Recording</in-capmkt:TypeOfAudioRecordingOrVideoRecording><in-capmkt:DateOfCallForAudioRecording contextRef="MainI">2026-10-23</in-capmkt:DateOfCallForAudioRecording><in-capmkt:TimeOfConclusionOfCallForAudioRecording contextRef="MainI">20:35:00</in-capmkt:TimeOfConclusionOfCallForAudioRecording><in-capmkt:DateOfDisclosureOfPriorIntimationOfEarningsCallToTheExchangeForAudioRecording contextRef="MainI">2026-10-07</in-capmkt:DateOfDisclosureOfPriorIntimationOfEarningsCallToTheExchangeForAudioRecording><in-capmkt:DateOfAudioRecordingUploadedOnWebsiteOfCompany contextRef="MainI">2026-10-23</in-capmkt:DateOfAudioRecordingUploadedOnWebsiteOfCompany><in-capmkt:TimeOfAudioRecordingUploadedOnWebsiteOfCompany contextRef="MainI">22:16:00</in-capmkt:TimeOfAudioRecordingUploadedOnWebsiteOfCompany><in-capmkt:WeblinkOfAudioRecording contextRef="MainI">https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.drreddys.com%2Fcms%2Fsites%2Fdefault%2Ffiles%2F2026-10%2FGMT20261023-140009_Recording.mp3&amp;data=05%7C02%7Csohansinghdhakad%40drreddys.com%7C9d64d22d27294a4723db08df3186f9dd%7C6d14682b68a64a25af3d06615e146b1e%7C0%7C0%7C639284127925546612%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=0NmnC5fV3JHLploX%2Fio2KWIfdiBJ3jm1pTWtSWp2mSQ%3D&amp;reserved=0</in-capmkt:WeblinkOfAudioRecording></xbrli:xbrl>