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<!--REG30 V1.0 (16-10-2025)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-08-31/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2025-08-31.xsd"/><xbrli:context id="OneI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/NSESymbol">PRAMODINI</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="OneD"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/NSESymbol">PRAMODINI</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-09-22</xbrli:startDate><xbrli:endDate>2026-09-22</xbrli:endDate></xbrli:period></xbrli:context><xbrli:unit id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><in-capmkt:ScripCode contextRef="OneI">000000</in-capmkt:ScripCode><in-capmkt:NameOfTheCompany contextRef="OneI">PRAMODINI MEDICARE LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:NSESymbol contextRef="OneI">PRAMODINI</in-capmkt:NSESymbol><in-capmkt:MSEISymbol contextRef="OneI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="OneI">INE2JG601017</in-capmkt:ISIN><in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">New</in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:TypeOfEventOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">Acquisition of “to be incorporated companies”</in-capmkt:TypeOfEventOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting contextRef="OneD">true</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting><in-capmkt:DateOfBoardMeeting contextRef="OneI">2026-09-09</in-capmkt:DateOfBoardMeeting><in-capmkt:EndTimeOfBoardMeeting contextRef="OneD">13:25:00</in-capmkt:EndTimeOfBoardMeeting><in-capmkt:DateOfReport contextRef="OneI">2026-09-22</in-capmkt:DateOfReport><in-capmkt:NameOfHoldingCompany contextRef="OneI">PRAMODINI MEDICARE LIMITED</in-capmkt:NameOfHoldingCompany><in-capmkt:RelationshipOfHoldingCompanyWithTheListedEntity contextRef="OneD">Listed Entity (self)</in-capmkt:RelationshipOfHoldingCompanyWithTheListedEntity><in-capmkt:NameOfTheIncorporatedEntity contextRef="OneI">SIDHEART ADVANCED HEALTHCARE PRIVATE LIMITED</in-capmkt:NameOfTheIncorporatedEntity><in-capmkt:IndustryToWhichTheEntityBeingIncorporatedBelongs contextRef="OneI">THE INDUSTRY FOR CARDIAC FACILITY IS HEALTHCARE</in-capmkt:IndustryToWhichTheEntityBeingIncorporatedBelongs><in-capmkt:BriefBackgroundAboutTheEntityIncorporatedInTermsOfProductsOrLineOfBusiness contextRef="OneI">To carry on the business of, and act as, the Concessionaire for the operation, maintenance and transfer of the cardiac facility established at the Kodagu Institute of Medical Sciences,
Madikeri, District Kodagu, Karnataka. 571201 (the Cardiac Facility), comprising a cardiac
catheterisation laboratory, 20 beds (9 general ward beds and 11 cardiac care unit beds), cardiac OPD and diagnostic services, on Operate, Maintain and Transfer (OMT) mode through Public Private Partnership (the Project), awarded pursuant to RFP No. DME/2025-26/SE0661 issued by the Directorate of Medical Education, Government of Karnataka, and to execute, perform and discharge all obligations of the Concessionaire under the Concession Agreement to be entered into with the Director &amp; Dean, Kodagu Institute of Medical Sciences, Madikeri (the Authority), including the Lease Agreement, Escrow Agreement and all other Project agreements, throughout the Concession Period of 10 (ten) years and any extension thereof, and to hand back the Cardiac Facility to the Authority in operational condition upon expiry or termination thereof.

In furtherance of and incidental to object 1 above, to operate, manage and maintain specialized cardiac hospitals, heart care centres, cardiology clinics, nursing homes, day-care centres, outpatient and inpatient facilities, ICCUs, diagnostic, pathology and imaging centres, laboratories, pharmacies, dispensaries and other allied healthcare facilities and to provide comprehensive cardiology, cardiac, cardiovascular and allied healthcare services, including consultation, diagnosis, investigation, preventive, therapeutic, interventional, surgical, emergency, critical care, rehabilitative and post-treatment services, through qualified medical and healthcare professionals, including non-invasive, minimally invasive, interventional and surgical procedures such as ECG, echocardiography, cardiac imaging, catheterisation, angiography, angioplasty, stent procedures, pacemaker implantation, electrophysiology, cardiac surgery, bypass and openheart surgery, and to undertake diagnostic, pathological, clinical, biochemical and imaging investigations; establish and operate pharmacies and procure, store, sell, supply and dispense medicines, medical devices, implants, equipment, consumables and other healthcare products; undertake and promote research, clinical research, studies, education, training, awareness programmes, seminars, conferences and continuing medical education in cardiology, cardiovascular healthcare and allied fields; and to acquire, develop, lease, license or otherwise provide land, buildings, infrastructure, equipment, technology and other facilities and undertake all activities incidental, ancillary or conducive thereto, subject to applicable laws, licences, permissions and regulatory approvals.

Provided that, for so long as the Concession Agreement subsists, the Company shall not undertake, carry on or engage in any business, activity or undertaking other than the Project and activities directly incidental or ancillary thereto, and the exercise of every object and
power herein shall be subject to, and shall not be inconsistent with, the terms of the concession Agreement.
</in-capmkt:BriefBackgroundAboutTheEntityIncorporatedInTermsOfProductsOrLineOfBusiness><in-capmkt:WhetherAnyGovernmentalOrRegulatoryApprovalsRequiredForTheIncorporation contextRef="OneD">NA</in-capmkt:WhetherAnyGovernmentalOrRegulatoryApprovalsRequiredForTheIncorporation><in-capmkt:NatureOfConsiderationForIncorporation contextRef="OneD">Cash</in-capmkt:NatureOfConsiderationForIncorporation><in-capmkt:AmountOfCashConsiderationForIncorporation contextRef="OneD" unitRef="INR" decimals="-7">0</in-capmkt:AmountOfCashConsiderationForIncorporation><in-capmkt:DetailsOfConsiderationForIncorporation contextRef="OneI">Pramodini Medicare Limited had made an investment of Rs. 30,000/- towards subscription of 3,000 Equity Shares of Rs. 10/- each in Sidheart Advanced Healthcare Private Limited.</in-capmkt:DetailsOfConsiderationForIncorporation><in-capmkt:CostOfSubscriptionOrThePriceAtWhichTheSharesAreSubscribed contextRef="OneD">Number of Shares</in-capmkt:CostOfSubscriptionOrThePriceAtWhichTheSharesAreSubscribed><in-capmkt:DetailsOfCostOfSubscriptionOrThePriceAtWhichTheSharesAreSubscribed contextRef="OneI">Pramodini Medicare Limited had made an investment of Rs. 30,000/- towards subscription of 3,000 Equity Shares of Rs. 10/- each in Sidheart Advanced Healthcare Private Limited.</in-capmkt:DetailsOfCostOfSubscriptionOrThePriceAtWhichTheSharesAreSubscribed><in-capmkt:PercentageOfShareholdingOrControl contextRef="OneI" unitRef="pure" decimals="INF">0.3</in-capmkt:PercentageOfShareholdingOrControl><in-capmkt:DateOfIncorporation contextRef="OneI">2026-09-21</in-capmkt:DateOfIncorporation><in-capmkt:CountryInWhichTheEntityIsIncorporated contextRef="OneI">INDIA</in-capmkt:CountryInWhichTheEntityIsIncorporated><in-capmkt:AnyOtherBriefSignificantInformationForIncorporationEvent contextRef="OneI">The Company will carry on the business of, and act as, the Concessionaire for the operation, maintenance and transfer of the cardiac facility established at the Kodagu Institute of Medical Sciences, Madikeri, District Kodagu, Karnataka</in-capmkt:AnyOtherBriefSignificantInformationForIncorporationEvent></xbrli:xbrl>
