<?xml version="1.0" encoding="UTF-8"?>
<!--REG30 V1.0 (16-10-2025)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-08-31/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2025-08-31.xsd"/><xbrli:context id="OneI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">544647</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-13</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="OneD"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">544647</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-13</xbrli:startDate><xbrli:endDate>2026-08-13</xbrli:endDate></xbrli:period></xbrli:context><in-capmkt:ScripCode contextRef="OneI">544647</in-capmkt:ScripCode><in-capmkt:NameOfTheCompany contextRef="OneI">Nephrocare Health Services Limited</in-capmkt:NameOfTheCompany><in-capmkt:NSESymbol contextRef="OneI">NEPHROPLUS</in-capmkt:NSESymbol><in-capmkt:MSEISymbol contextRef="OneI">NA</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="OneI">INE428V01029</in-capmkt:ISIN><in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">Update</in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting contextRef="OneD">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting><in-capmkt:DateOfOccurrenceOfEvent contextRef="OneI">2026-08-12</in-capmkt:DateOfOccurrenceOfEvent><in-capmkt:TimeOfOccurrenceOfEvent contextRef="OneD">18:00:00</in-capmkt:TimeOfOccurrenceOfEvent><in-capmkt:DateOfInitialAnnouncement contextRef="OneI">2026-05-26</in-capmkt:DateOfInitialAnnouncement><in-capmkt:DateOfLatestAnnouncement contextRef="OneI">2026-08-12</in-capmkt:DateOfLatestAnnouncement><in-capmkt:DateOfReport contextRef="OneI">2026-08-13</in-capmkt:DateOfReport><in-capmkt:UpdateForTheEvent contextRef="OneD">Acquisition of “to be incorporated companies”</in-capmkt:UpdateForTheEvent><in-capmkt:BriefDetailsOfInitialAnnouncement contextRef="OneI">NPHSK LLP has been incorporated with the objective of undertaking holding and management activities to expand its kidney care and dialysis services network in Kazakhstan. In furtherance of this objective, NPHSK LLP shall engage in all activities that are incidental or
ancillary thereto, including, but not limited to, the establishment and operation of dialysis centres, procurement of medical equipment and consumables, and the provision of comprehensive patient care and related healthcare services.</in-capmkt:BriefDetailsOfInitialAnnouncement><in-capmkt:ReasonForUpdate contextRef="OneD">Transaction Modification</in-capmkt:ReasonForUpdate><in-capmkt:TransactionModification contextRef="OneI">With reference to the disclosure made by the Company on May 26, 2026 regarding the incorporation of NEPHROPLUS HEALTH SERVICES KAZAKHSTAN Limited Liability Partnership (“NPHSK LLP”) in the Republic of Kazakhstan, we wish to clarify that NPHSK LLP was inadvertently referred to in the said disclosure as a step-down wholly owned subsidiary of the Company. In this regard, it is clarified that Nephrocare Health Services International Pte. Ltd. (“NHSI”), Singapore, a wholly owned subsidiary of the Company, holds 99% of the charter capital of NPHSK LLP, with the balance 1% being held by another participant. Accordingly, NPHSK LLP is a step-down subsidiary of the Company and not a step-down wholly owned subsidiary. This clarification is being submitted to appropriately reflect the status of NPHSK LLP, and all other information contained in the earlier disclosure remains unchanged.</in-capmkt:TransactionModification></xbrli:xbrl>
