<?xml version="1.0" encoding="UTF-8"?>
<!--REG30 V1.0 (16-10-2025)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-08-31/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2025-08-31.xsd"/><xbrli:context id="OneI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">542650</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-07</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="OneD"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">542650</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-09-07</xbrli:startDate><xbrli:endDate>2026-09-07</xbrli:endDate></xbrli:period></xbrli:context><in-capmkt:ScripCode contextRef="OneI">542650</in-capmkt:ScripCode><in-capmkt:NameOfTheCompany contextRef="OneI">Metropolis Healthcare Limited</in-capmkt:NameOfTheCompany><in-capmkt:NSESymbol contextRef="OneI">METROPOLIS</in-capmkt:NSESymbol><in-capmkt:MSEISymbol contextRef="OneI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="OneI">INE112L01020</in-capmkt:ISIN><in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">New</in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:TypeOfEventOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">Other Restructuring</in-capmkt:TypeOfEventOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting contextRef="OneD">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting><in-capmkt:DateOfOccurrenceOfEvent contextRef="OneI">2026-09-07</in-capmkt:DateOfOccurrenceOfEvent><in-capmkt:TimeOfOccurrenceOfEvent contextRef="OneD">17:30:00</in-capmkt:TimeOfOccurrenceOfEvent><in-capmkt:DateOfReport contextRef="OneI">2026-09-07</in-capmkt:DateOfReport><in-capmkt:DetailsAndReasonsForOtherRestructuring contextRef="OneI">Metropolis Quality Solutions Private Limited (“MQSPL”), a subsidiary of Metropolis Healthcare Limited (“the Company/MHL”), has approved and entered into:
(a)	the Share Subscription Agreement with Medsource Ozone Biomedicals Private Limited (“Medsource”) and Dr. Puneet Kumar Nigam; and 
(b)	the Shareholder’s Agreement (“SHA”) with Medsource, MHL and Dr. Puneet Kumar Nigam. 

Reason for Restructuring: The restructuring is intended to consolidate and streamline the External Quality Assessment Services Business under MQSPL, by bringing together the operational leadership, clinical / diagnostic backing, R&amp;D, and product development capabilities required to scale the business.</in-capmkt:DetailsAndReasonsForOtherRestructuring><in-capmkt:QuantitativeEffectOfOtherRestructuring contextRef="OneI">Medsource and Dr. Puneet will invest approximately INR 1.10 crore and INR 16 lakh, respectively, in MQSPL.

Presently, MQSPL is a wholly owned subsidiary of MHL. Upon consummation of the Transaction and subject to fulfilment of the applicable terms and conditions governing the conversion, in tranches over a period of 5 (five) years, of the 10,000 Optionally Convertible Redeemable Preference Shares issued to Dr. Puneet Kumar Nigam, the shareholding structure of MQSPL, on a fully diluted basis, shall be as follows: MHL – 54.90%; Medsource – 30.60%; and Dr. Puneet – 14.50%.</in-capmkt:QuantitativeEffectOfOtherRestructuring><in-capmkt:QualitativeEffectOfOtherRestructuring contextRef="OneI">MHL and Medsource shall have the right to nominate Directors on the Board of MQSPL, subject to the terms of the SHA. The protective/reserved matters, along with the clearly defined roles, responsibilities, rights and obligations of each Party, shall be as set out in the SHA.</in-capmkt:QualitativeEffectOfOtherRestructuring><in-capmkt:WhetherThePromoterOrPromoterGroupOrGroupCompaniesIncludingAssociateOrHoldingOrSubsidiaryOrDirectorOrKMPOrSMPAndItsRelativesHaveAnyInterestInTheEntityBeingRestructuring contextRef="OneD">false</in-capmkt:WhetherThePromoterOrPromoterGroupOrGroupCompaniesIncludingAssociateOrHoldingOrSubsidiaryOrDirectorOrKMPOrSMPAndItsRelativesHaveAnyInterestInTheEntityBeingRestructuring><in-capmkt:BriefDetailsOfChangeInShareholdingPatternOfAllEntitiesForOtherRestructuring contextRef="OneI">Presently, MQSPL is a wholly owned subsidiary of MHL. Upon consummation of the Transaction and subject to fulfilment of the applicable terms and conditions governing the conversion, in tranches over a period of 5 (five) years, of the 10,000 Optionally Convertible Redeemable Preference Shares issued to Dr. Puneet Kumar Nigam, the shareholding structure of MQSPL, on a fully diluted basis, shall be as follows: MHL – 54.90%; Medsource – 30.60%; and Dr. Puneet – 14.50%.</in-capmkt:BriefDetailsOfChangeInShareholdingPatternOfAllEntitiesForOtherRestructuring></xbrli:xbrl>
