<?xml version="1.0" encoding="UTF-8" standalone="no"?><xbrli:xbrl xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:in-capmkt="https://www.sebi.gov.in/xbrl/2022-12-31/in-capmkt" xmlns:in-capmkt-ent="https://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2022-12-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="https://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2022-12-31/in-capmkt-roles" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:xlink="http://www.w3.org/1999/xlink"><link:schemaRef xlink:href="in-capmkt-ent-2022-12-31.xsd" xlink:type="simple"/><xbrli:context id="OneI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ISIN">543904</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2025-05-02</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="OneD"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ISIN">543904</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2025-05-02</xbrli:startDate><xbrli:endDate>2025-05-02</xbrli:endDate></xbrli:period></xbrli:context><in-capmkt:NameOfTheCompany contextRef="OneI">MANKIND PHARMA LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:NSESymbol contextRef="OneI">MANKIND</in-capmkt:NSESymbol><in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">Update</in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:DateOfEventOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneI">2025-05-02</in-capmkt:DateOfEventOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:DateOfInitialAnnouncement contextRef="OneI">2024-11-15</in-capmkt:DateOfInitialAnnouncement><in-capmkt:DateOfLatestAnnouncement contextRef="OneI">2025-01-07</in-capmkt:DateOfLatestAnnouncement><in-capmkt:DateOfReport contextRef="OneI">2025-05-02</in-capmkt:DateOfReport><in-capmkt:BriefDetailsOfInitialAnnouncement contextRef="OneI">Creation of Pledge on the shares of Bharat Serums and Vaccines Limited, wholly owned subsidiary of the Company</in-capmkt:BriefDetailsOfInitialAnnouncement><in-capmkt:ReasonForUpdate contextRef="OneD">Others</in-capmkt:ReasonForUpdate><in-capmkt:OtherUpdates contextRef="OneI">This has reference to our earlier communication dated January 7, 2025 in respect of creation of pledge equal to 95.99% equity shares of Bharat Serums and Vaccines Limited (“BSV”), a wholly owned subsidiary of the Company, in favour of Catalyst Trusteeship Limited as the Common Security Trustee for the benefit of the holders of the listed, rated, secured, redeemable, transferable Non-Convertible Debentures (NCDs), aggregating to INR 5,000 crores issued by the Company in 3 series.
We now wish to inform you that, as per terms and conditions of Debenture Trust Deeds, the security cover provided for the aforesaid NCDs was in excess of the mandatory threshold as prescribed under the Debenture Trust Deeds and accordingly, out of the total 95.99% equity shares of BSV pledged as aforesaid, equity shares representing 57.31% have been released today, i.e., May 02, 2025.</in-capmkt:OtherUpdates></xbrli:xbrl>