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<!--REG30 V1.0 (16-10-2025)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-08-31/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="http://www.sebi.gov.in/xbrl/Regulation_30_Restructuring/2025-08-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2025-08-31.xsd"/><xbrli:context id="OneI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/NSESymbol">THYROCARE</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-21</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="OneD"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/NSESymbol">THYROCARE</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-09-21</xbrli:startDate><xbrli:endDate>2026-09-21</xbrli:endDate></xbrli:period></xbrli:context><xbrli:unit id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><in-capmkt:ScripCode contextRef="OneI">539871</in-capmkt:ScripCode><in-capmkt:NameOfTheCompany contextRef="OneI">Thyrocare Technologies Limited</in-capmkt:NameOfTheCompany><in-capmkt:NSESymbol contextRef="OneI">THYROCARE</in-capmkt:NSESymbol><in-capmkt:MSEISymbol contextRef="OneI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="OneI">INE594H01019</in-capmkt:ISIN><in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">New</in-capmkt:TypeOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:TypeOfEventOfAnnouncementPertainingToRegulation30Restructuring contextRef="OneD">Acquisition (including agreement to acquire)</in-capmkt:TypeOfEventOfAnnouncementPertainingToRegulation30Restructuring><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting contextRef="OneD">true</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting><in-capmkt:DateOfBoardMeeting contextRef="OneI">2026-09-21</in-capmkt:DateOfBoardMeeting><in-capmkt:EndTimeOfBoardMeeting contextRef="OneD">14:50:00</in-capmkt:EndTimeOfBoardMeeting><in-capmkt:DateOfReport contextRef="OneI">2026-09-21</in-capmkt:DateOfReport><in-capmkt:RemarksForWebsiteDissemination contextRef="OneI">Sale and transfer of the entire equity shareholding held by the Company in Nueclear Healthcare Limited (“NHL”), a material wholly owned subsidiary of the Company , comprising 1,11,11,000 (One Crore Eleven Lakh Eleven Thousand) equity shares, representing 100% of the issued, subscribed and paid-up equity share capital of NHL, to Trovera Healthcare Private Limited (“Trovera” or “Purchaser”), pursuant to a Share Purchase Agreement (“SPA”). &lt;BR&gt; 
 &lt;BR&gt; 
The acquisition of the CCPS is being undertaken as part of the consideration for the proposed sale of the Company's entire shareholding in NHL to Trovera. The Company will acquire 42,500 CCPS of Trovera, having a face value of Rs. 10/- each and issued at a premium of Rs. 13,990/- per CCPS, as part consideration for the proposed sale. The balance consideration will be payable in cash. &lt;BR&gt; 
 &lt;BR&gt; 
The acquisition of the CCPS is directly linked to and forms part of the consideration for the sale of the Company's entire shareholding in NHL.  Accordingly, for share swap ratio, we have mentioned 1:1 only for validation purpose</in-capmkt:RemarksForWebsiteDissemination><in-capmkt:NameOfAcquirer contextRef="OneI">Thyrocare Technologies Limited</in-capmkt:NameOfAcquirer><in-capmkt:RelationshipOfAcquirerWithTheListedEntity contextRef="OneD">Listed Entity (self)</in-capmkt:RelationshipOfAcquirerWithTheListedEntity><in-capmkt:NameOfTheTargetEntity contextRef="OneI">Trovera Healthcare Private Limited</in-capmkt:NameOfTheTargetEntity><in-capmkt:TurnoverOfTargetEntity contextRef="OneD" unitRef="INR" decimals="-7">0</in-capmkt:TurnoverOfTargetEntity><in-capmkt:ProfitAfterTaxOfTargetEntity contextRef="OneD" unitRef="INR" decimals="-7">0</in-capmkt:ProfitAfterTaxOfTargetEntity><in-capmkt:NetWorthOfTargetEntity contextRef="OneD" unitRef="INR" decimals="-7">0</in-capmkt:NetWorthOfTargetEntity><in-capmkt:OtherFinancialParameterOfTargetEntity contextRef="OneI">Trovera Healthcare Private Limited was incorporated on June 16, 2026 and does not have latest audited financial parameter.</in-capmkt:OtherFinancialParameterOfTargetEntity><in-capmkt:WhetherTheAcquisitionWouldFallWithinRelatedPartyTransactions contextRef="OneD">false</in-capmkt:WhetherTheAcquisitionWouldFallWithinRelatedPartyTransactions><in-capmkt:WhetherThePromoterOrPromoterGroupOrGroupCompaniesIncludingAssociateOrHoldingOrSubsidiaryOrDirectorOrKMPOrSMPAndItsRelativesHaveAnyInterestInTheEntityBeingAcquired contextRef="OneD">false</in-capmkt:WhetherThePromoterOrPromoterGroupOrGroupCompaniesIncludingAssociateOrHoldingOrSubsidiaryOrDirectorOrKMPOrSMPAndItsRelativesHaveAnyInterestInTheEntityBeingAcquired><in-capmkt:WhetherAcquisitionEventIsDoneAtArmsLength contextRef="OneD">true</in-capmkt:WhetherAcquisitionEventIsDoneAtArmsLength><in-capmkt:IndustryToWhichTheEntityBeingAcquiredBelongs contextRef="OneI">Healthcare Services</in-capmkt:IndustryToWhichTheEntityBeingAcquiredBelongs><in-capmkt:ObjectsAndImpactOfAcquisitionIncludingButNotLimitedToDisclosureOfReasonsForAcquisitionOfTargetEntityIfItsBusinessIsOutsideTheMainLineOfBusinessOfTheListedEntity contextRef="OneI">The acquisition of the CCPS of Trovera forms part of the consideration for the proposed sale of the Company's entire shareholding in NHL. Trovera's business is within the broad healthcare and diagnostics sector, which is aligned with the Company's business. The acquisition of the CCPS is directly linked to and incidental to the proposed divestment of NHL</in-capmkt:ObjectsAndImpactOfAcquisitionIncludingButNotLimitedToDisclosureOfReasonsForAcquisitionOfTargetEntityIfItsBusinessIsOutsideTheMainLineOfBusinessOfTheListedEntity><in-capmkt:WhetherAnyGovernmentalOrRegulatoryApprovalsRequiredForTheAcquisition contextRef="OneD">No</in-capmkt:WhetherAnyGovernmentalOrRegulatoryApprovalsRequiredForTheAcquisition><in-capmkt:WhetherTheAcquisitionTransactionWillBeInTranches contextRef="OneD">false</in-capmkt:WhetherTheAcquisitionTransactionWillBeInTranches><in-capmkt:IndicativeTimePeriodForCompletionOfTheAcquisition contextRef="OneI">The acquisition is expected to be completed by November, 30, 2026, subject to satisfaction of the applicable conditions precedent and receipt of requisite approvals.</in-capmkt:IndicativeTimePeriodForCompletionOfTheAcquisition><in-capmkt:NatureOfConsiderationForAcquisitionEvent contextRef="OneD">Cash and Shares</in-capmkt:NatureOfConsiderationForAcquisitionEvent><in-capmkt:ShareExchangeRatioForAcquisitionEvent contextRef="OneD">1:1</in-capmkt:ShareExchangeRatioForAcquisitionEvent><in-capmkt:AmountOfCashConsiderationForAcquisitionEvent contextRef="OneD" unitRef="INR" decimals="-6">819000000</in-capmkt:AmountOfCashConsiderationForAcquisitionEvent><in-capmkt:DetailsOfConsiderationForAcquisitionEvent contextRef="OneI">The acquisition of the CCPS is being undertaken as part of the consideration for the proposed sale of the Company's entire shareholding in NHL to Trovera. The Company will acquire 42,500 CCPS of Trovera, having a face value of Rs. 10/- each and issued at a premium of Rs. 13,990/- per CCPS, as part consideration for the proposed sale. The balance consideration will be payable in cash.</in-capmkt:DetailsOfConsiderationForAcquisitionEvent><in-capmkt:CostOfAcquisitionOrThePriceAtWhichTheSharesAreAcquired contextRef="OneD" unitRef="INR" decimals="-6">595000000</in-capmkt:CostOfAcquisitionOrThePriceAtWhichTheSharesAreAcquired><in-capmkt:ExistingPercentageOfShareholdingHeldByAcquirer contextRef="OneI" unitRef="pure" decimals="INF">0</in-capmkt:ExistingPercentageOfShareholdingHeldByAcquirer><in-capmkt:PercentageOfControlAcquired contextRef="OneI" unitRef="pure" decimals="INF">0</in-capmkt:PercentageOfControlAcquired><in-capmkt:PercentageOfAdditionalSharesAcquiredIfExistingHoldingPersists contextRef="OneI" unitRef="pure" decimals="INF">0</in-capmkt:PercentageOfAdditionalSharesAcquiredIfExistingHoldingPersists><in-capmkt:BriefBackgroundAboutTheEntityAcquiredInTermsOfProductsLineOfBusinessAcquired contextRef="OneI">Trovera Healthcare Private Limited was incorporated on June 16, 2026 and is engaged in the business of healthcare and diagnostic services. As the company was incorporated during FY 2026-27, audited turnover for the preceding three financial years is not applicable. Trovera has presence in India.</in-capmkt:BriefBackgroundAboutTheEntityAcquiredInTermsOfProductsLineOfBusinessAcquired><in-capmkt:DateOfIncorporationForAcquisitionEvent contextRef="OneI">2026-06-16</in-capmkt:DateOfIncorporationForAcquisitionEvent><in-capmkt:CountryInWhichTheAcquiredEntityHasPresence contextRef="OneI">India</in-capmkt:CountryInWhichTheAcquiredEntityHasPresence><in-capmkt:AnyOtherBriefSignificantInformationForTheAcquisition contextRef="OneI">The sale and transfer of the entire equity shareholding held by the Company in Nueclear Healthcare Limited (“NHL”), a material wholly owned subsidiary of the Company , comprising 1,11,11,000 (One Crore Eleven Lakh Eleven Thousand) equity shares, representing 100% of the issued, subscribed and paid-up equity share capital of NHL, to Trovera Healthcare Private Limited (“Trovera” or “Purchaser”), pursuant to a Share Purchase Agreement (“SPA”).
As part of the consideration for the proposed sale of the Company's entire shareholding in Nueclear Healthcare Limited, Material Wholly Owned Subsidiary Company of the Company to Trovera, the Company will acquire 42,500 (Forty-Two Thousand Five Hundred) CCPS of Trovera. 

The CCPS will have a face value of Rs. 10/- (Rupees Ten only) each and will be issued at a premium of Rs. 13,990/- (Rupees Thirteen Thousand Nine Hundred Ninety only) per CCPS, in accordance with the agreed share swap terms and subject to the terms and conditions set out in the proposed SPA. 

The acquisition of the CCPS is directly linked to and forms part of the consideration for the sale of the Company's entire shareholding in NHL.</in-capmkt:AnyOtherBriefSignificantInformationForTheAcquisition></xbrli:xbrl>
