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<!--REG30PARAB V1.0 (01-06-2026)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Para_B_Of_Part_A_Of_Schedule_III/2026-04-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2026-04-30.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/NSESymbol">DRREDDY</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-21</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="I_ArrangementsForStrategicOrTechnicalOrManufacturingOrMarketingTieUp"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/NSESymbol">DRREDDY</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-21</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:explicitMember dimension="in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIIIAxis">in-capmkt:ArrangementsForStrategicOrTechnicalOrManufacturingOrMarketingTieUpMember</xbrldi:explicitMember></xbrli:scenario></xbrli:context><in-capmkt:NSESymbol contextRef="MainI">DRREDDY</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">DR. REDDY'S LABORATORIES LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">500124</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE089A01031</in-capmkt:ISIN><in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">Arrangement/Adoption of new line/Closure of operations (Sub-para 2-Para B)</in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="I_ArrangementsForStrategicOrTechnicalOrManufacturingOrMarketingTieUp">Arrangements for strategic, technical, manufacturing, or marketing tie up</in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">New</in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting contextRef="MainI">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainI">2026-09-18</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainI">08:50:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:DateOfReport contextRef="MainI">2026-09-21</in-capmkt:DateOfReport><in-capmkt:TypeOfArrangement contextRef="MainI">Agreement</in-capmkt:TypeOfArrangement><in-capmkt:NameOfEntitiesWithWhomAgreementOrJointVentureIsSigned contextRef="MainI">Takeda Biopharmaceuticals India Private Limited</in-capmkt:NameOfEntitiesWithWhomAgreementOrJointVentureIsSigned><in-capmkt:AreaOfAgreementOrJointVenture contextRef="MainI">Exclusive distribution and marketing of Qdenga® in the private market in India</in-capmkt:AreaOfAgreementOrJointVenture><in-capmkt:WhetherArrangementIsDomesticOrInternational contextRef="MainI">Domestic</in-capmkt:WhetherArrangementIsDomesticOrInternational><in-capmkt:ShareExchangeRatioOrJointVentureRatio contextRef="MainI">Not Applicable</in-capmkt:ShareExchangeRatioOrJointVentureRatio><in-capmkt:ScopeOfBusinessOperationOfAgreementOrJointVenture contextRef="MainI">Pursuant to terms of the Agreement, Dr. Reddy’s will be exclusively responsible for distribution and marketing of Qdenga® in the private market in India, while Takeda will retain commercialization rights in the public market in India, and will be responsible for manufacturing and importation of the vaccine.</in-capmkt:ScopeOfBusinessOperationOfAgreementOrJointVenture><in-capmkt:DetailsOfConsiderationPaidOrReceivedInAgreementOrJointVenture contextRef="MainI">There is no upfront consideration or milestone payment under the agreement. Other commercial terms are confidential in nature.</in-capmkt:DetailsOfConsiderationPaidOrReceivedInAgreementOrJointVenture><in-capmkt:SignificantTermsAndConditionsOfAgreementOrJointVenture contextRef="MainI">Pursuant to the terms of the Agreement, Dr. Reddy’s has exclusive distribution and marketing rights for Qdenga® in the private market in India.</in-capmkt:SignificantTermsAndConditionsOfAgreementOrJointVenture><in-capmkt:WhetherTheAcquisitionWouldFallWithinRelatedPartyTransactions contextRef="MainI">false</in-capmkt:WhetherTheAcquisitionWouldFallWithinRelatedPartyTransactions><in-capmkt:SizeOfEntityInArrangement contextRef="MainI">Not Applicable</in-capmkt:SizeOfEntityInArrangement><in-capmkt:RationaleAndExpectedBenefitOfArrangement contextRef="MainI">The partnership is aligned with Dr. Reddy's strategy to strengthen its vaccines business in India and supports broader public health efforts aimed at addressing the significant burden of dengue in India.</in-capmkt:RationaleAndExpectedBenefitOfArrangement></xbrli:xbrl>
