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<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Para_B_Of_Part_A_Of_Schedule_III/2026-04-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2026-04-30.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">544172</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="I_AtTheTimeOfBecomingPartyToLitigationOrAssessmentOrAdjudicationOrArbitrationOrDispute"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">544172</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-19</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:explicitMember dimension="in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIIIAxis">in-capmkt:AtTheTimeOfBecomingPartyToLitigationOrAssessmentOrAdjudicationOrArbitrationOrDisputeMember</xbrldi:explicitMember></xbrli:scenario></xbrli:context><xbrli:context id="I_StageOfTheLitigationIsConcludedOrDisputeIsResolved"><xbrli:entity><xbrli:identifier 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id="I_DevelopmentInRelationToProceedings"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">544172</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-19</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:explicitMember dimension="in-capmkt:StageOfTheLitigationIsConcludedOrDisputeIsResolvedAsPerSubPara8OfParaBAxis">in-capmkt:DevelopmentInRelationToProceedingsMember</xbrldi:explicitMember></xbrli:scenario></xbrli:context><in-capmkt:NSESymbol contextRef="MainI">INDGN</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">INDEGENE LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">544172</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE065X01017</in-capmkt:ISIN><in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">Pendency of any litigation(s) or dispute(s) (Sub-para 8-Para B)</in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="I_AtTheTimeOfBecomingPartyToLitigationOrAssessmentOrAdjudicationOrArbitrationOrDispute">At the time of becoming the party to any litigation, assessment, adjudication, arbitration or dispute</in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="I_StageOfTheLitigationIsConcludedOrDisputeIsResolved">Regularly till the litigation is concluded or dispute is resolved</in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">New</in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting contextRef="MainI">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainI">2026-08-18</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainI">16:00:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:DateOfReport contextRef="MainI">2026-08-19</in-capmkt:DateOfReport><in-capmkt:NameOfOppositeParties contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Progressive Health and Rehab Corp., individually and on behalf of a certified class.</in-capmkt:NameOfOppositeParties><in-capmkt:DateOfInitiationOfLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">2025-07-17</in-capmkt:DateOfInitiationOfLitigation><in-capmkt:NameOfAuthorityWhereLitigationIsFiled contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Court</in-capmkt:NameOfAuthorityWhereLitigationIsFiled><in-capmkt:DetailsOfAuthorityWhereLitigationIsFiled contextRef="I_OppositePartyAsPerSubPara8OfParaB1">U.S. District Court, District of New Jersey</in-capmkt:DetailsOfAuthorityWhereLitigationIsFiled><in-capmkt:PartyToTheLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Subsidiary</in-capmkt:PartyToTheLitigation><in-capmkt:DetailsOfPartyToTheLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Indegene, Inc</in-capmkt:DetailsOfPartyToTheLitigation><in-capmkt:BriefDetailsOfLitigationOrDispute contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Class action litigation alleging violations of the U.S. Telephone Consumer Protection Act, 1991 in connection with certain alleged unsolicited fax communications. In July 2025, the Court certified a class comprising approximately 18,851 unique fax numbers (18,869 transmissions). 

The defendants' petition seeking permission to appeal the class certification was subsequently denied. The matter thereafter proceeded through mediation and settlement negotiations.</in-capmkt:BriefDetailsOfLitigationOrDispute><in-capmkt:ExpectedFinancialImplicationsOfLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">The settlement framework provides for a maximum settlement fund of approximately USD 4.72 million, calculated at USD 250 per eligible fax/claim under the agreed framework.

The settlement is structured on a claims-made and reversionary basis, under which the actual amount payable to class members will depend upon the number of valid and approved claims submitted. Amounts not required to satisfy approved claims and other payments contemplated under the settlement will remain with/revert to the defendants in accordance with the settlement terms.

The defendants are not required to deposit or pre-fund the entire USD 4.72 million settlement fund, and payments will become due in accordance with the settlement agreement and Court-approved process. The Company has assessed/shall assess the accounting impact in accordance with applicable accounting standards.</in-capmkt:ExpectedFinancialImplicationsOfLitigation><in-capmkt:QuantumOfClaimsInLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">The certified class comprises approximately 18,851 unique fax numbers relating to 18,869 transmissions. The agreed settlement framework provides for USD 250 per eligible approved claim, subject to the terms and conditions of the definitive settlement agreement.

The resulting maximum settlement fund is approximately USD 4.72 million; however, this represents the contractual maximum and not the expected cash outflow, since the settlement is claims-made and actual payments will depend on valid claims received and approved.</in-capmkt:QuantumOfClaimsInLitigation><in-capmkt:StageOfDisclosureOfLitigationOrDispute contextRef="I_DevelopmentInRelationToProceedings">Development in relation to proceedings</in-capmkt:StageOfDisclosureOfLitigationOrDispute><in-capmkt:DetailsOfLitigationOrDisputeForWhichDisclosureIsBeingMade contextRef="I_DevelopmentInRelationToProceedings">Class action litigation alleging violations of the U.S. Telephone Consumer Protection Act, 1991 in connection with certain alleged unsolicited fax communications. In July 2025, the Court certified a class comprising approximately 18,851 unique fax numbers (18,869 transmissions). 

The defendants' petition seeking permission to appeal the class certification was subsequently denied. The matter thereafter proceeded through mediation and settlement negotiations.</in-capmkt:DetailsOfLitigationOrDisputeForWhichDisclosureIsBeingMade><in-capmkt:DateOfOriginalLitigationDisclosure contextRef="I_DevelopmentInRelationToProceedings">2024-04-26</in-capmkt:DateOfOriginalLitigationDisclosure><in-capmkt:DetailsOfDevelopmentInRelationToTheExistingProceedings contextRef="I_DevelopmentInRelationToProceedings">Since the Company's previous disclosure, the settlement has progressed from mediation and negotiation of settlement documentation to finalization of the definitive settlement agreement from the Company's perspective.
External counsel circulated the finalized settlement agreement for execution and, following resolution/clarification of the remaining points, the Company confirmed that it has no further comments and authorized the agreement to proceed for signature.

The agreed notice mechanics contemplate an initial fax notice and, where unsuccessful, notice by U.S. First Class Mail. The parties have identified Analytics as settlement administrator at an estimated administration cost of approximately USD 42,559. The settlement does not require upfront funding or escrow of the maximum settlement fund.

The next steps are execution by the relevant parties, filing of the settlement documentation with the Court, preliminary approval, class notice and claims administration, followed by final Court approval.</in-capmkt:DetailsOfDevelopmentInRelationToTheExistingProceedings><in-capmkt:LitigationAgainstParty contextRef="I_DevelopmentInRelationToProceedings">Others</in-capmkt:LitigationAgainstParty><in-capmkt:DetailsOfOtherLitigationAgainstParty contextRef="I_DevelopmentInRelationToProceedings">The litigation is against Indegene, Inc. and certain subsidiaries and does not relate to litigation against the Company's key managerial personnel or ultimate person in control.</in-capmkt:DetailsOfOtherLitigationAgainstParty></xbrli:xbrl>
