<?xml version="1.0" encoding="UTF-8"?>
<!--REG30PARAB V1.0 (01-06-2026)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Para_B_Of_Part_A_Of_Schedule_III/2026-04-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2026-04-30.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">540937</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-05</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="I_BaggingOrReceivingOfOrdersOrContracts"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">540937</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-05</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:explicitMember dimension="in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIIIAxis">in-capmkt:BaggingOrReceivingOfOrdersOrContractsMember</xbrldi:explicitMember></xbrli:scenario></xbrli:context><xbrli:context id="I_BaggingOrReceivingOfOrdersOrContractsMember"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">540937</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-05</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:explicitMember dimension="in-capmkt:AwardingOrBaggingOrReceivingOrAmendmentOrTerminationOfOrdersOrContractsAsPerSubPara4OfParaBAxis">in-capmkt:BaggingOrReceivingOfOrdersOrContractsMember</xbrldi:explicitMember></xbrli:scenario></xbrli:context><xbrli:unit id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><in-capmkt:NSESymbol contextRef="MainI">MEDICO</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">MEDICO REMEDIES LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">540937</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE630Y01024</in-capmkt:ISIN><in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">Awarding, Bagging/Receiving, Amendment or termination of orders/contracts (Sub-para 4-Para B)</in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="I_BaggingOrReceivingOfOrdersOrContracts">Bagging/Receiving of orders/contracts</in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">New</in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting contextRef="MainI">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainI">2026-08-05</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainI">00:00:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:DateOfReport contextRef="MainI">2026-08-05</in-capmkt:DateOfReport><in-capmkt:NameOfTheEntityAwardingTheOrdersOrContracts contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">PROMESE/CAL (Programa de Medicamentos Esenciales y
Central de Logística)</in-capmkt:NameOfTheEntityAwardingTheOrdersOrContracts><in-capmkt:WhetherTheOrdersOrContractsIsOrdinaryCourseOfBusiness contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">true</in-capmkt:WhetherTheOrdersOrContractsIsOrdinaryCourseOfBusiness><in-capmkt:WhetherOrdersOrContractsIsAwardedByDomesticOrInternationalEntity contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">International</in-capmkt:WhetherOrdersOrContractsIsAwardedByDomesticOrInternationalEntity><in-capmkt:WhetherTheCounterpartyIsIndianListedEntity contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">false</in-capmkt:WhetherTheCounterpartyIsIndianListedEntity><in-capmkt:LEIOrCINOrRegistrationNumberOfTheCounterparty contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">NA</in-capmkt:LEIOrCINOrRegistrationNumberOfTheCounterparty><in-capmkt:WhetherTheCounterpartyBelongsToGroupCompaniesOfAnyIndianListedEntity contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">false</in-capmkt:WhetherTheCounterpartyBelongsToGroupCompaniesOfAnyIndianListedEntity><in-capmkt:NameOfTheCountryInWhichCounterpartyIsExists contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">Dominican Republic</in-capmkt:NameOfTheCountryInWhichCounterpartyIsExists><in-capmkt:DateOfBaggingOrReceivingOfOrdersOrContracts contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">2026-08-05</in-capmkt:DateOfBaggingOrReceivingOfOrdersOrContracts><in-capmkt:AmountOfTheOrdersOrContracts contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember" unitRef="INR" decimals="0">133800000</in-capmkt:AmountOfTheOrdersOrContracts><in-capmkt:SignificantTermsAndConditionsOfOrdersOrContractsIsAwarded contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">PROMESE/CAL (Programa de Medicamentos Esenciales y Central de Logística) is the program responsible for the centralized purchase and distribution of medicines, health supplies and laboratory reagents that meets the demand of the National Public Health System in the Country of Dominican Republic. Medico Remedies Ltd has secured the order to supply tablets, capsules and dry syrups to PROMESE/CAL and will complete the supply of the full order within 3 months.</in-capmkt:SignificantTermsAndConditionsOfOrdersOrContractsIsAwarded><in-capmkt:NatureOfOrdersOrContracts contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">The Company has secured government order for supply of tablets, capsules and dry syrups to PROMESE/CAL</in-capmkt:NatureOfOrdersOrContracts><in-capmkt:TimePeriodByWhichTheOrdersOrContractsIsToBeExecuted contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">The Company will complete the supply of the full order within 3 months.</in-capmkt:TimePeriodByWhichTheOrdersOrContractsIsToBeExecuted><in-capmkt:BroadConsiderationForTheOrdersOrContracts contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">Order Value approximately of USD 1406450 (One Million, Four Hundred Six Thousand, Four Hundred Fifty US dollars) equivalent to approximately INR 13.38 Crores.</in-capmkt:BroadConsiderationForTheOrdersOrContracts><in-capmkt:WhetherThePromoterOrPromoterGroupOrGroupCompaniesHaveAnyInterestInThatEntityToWhomTheOrdersOrContractsIsAwarded contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">false</in-capmkt:WhetherThePromoterOrPromoterGroupOrGroupCompaniesHaveAnyInterestInThatEntityToWhomTheOrdersOrContractsIsAwarded><in-capmkt:WhetherTheOrderOrContractWouldFallWithinRelatedPartyTransactions contextRef="I_BaggingOrReceivingOfOrdersOrContractsMember">false</in-capmkt:WhetherTheOrderOrContractWouldFallWithinRelatedPartyTransactions></xbrli:xbrl>