<?xml version="1.0" encoding="UTF-8"?>
<!--REG30PARAB V1.0 (01-06-2026)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Para_B_Of_Part_A_Of_Schedule_III/2026-04-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2026-04-30.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">544476</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-09</xbrli:instant></xbrli:period></xbrli:context><in-capmkt:NSESymbol contextRef="MainI">JSLL</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">Jeena Sikho Lifecare Limited</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">544476</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE0J5801029</in-capmkt:ISIN><in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">Commencement or postponement (Sub-para 1-Para B)</in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">New</in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting contextRef="MainI">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainI">2026-09-09</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainI">12:04:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:DateOfReport contextRef="MainI">2026-09-09</in-capmkt:DateOfReport><in-capmkt:DisclosureForUnitOrDivisionOfTheCompany contextRef="MainI">Unit</in-capmkt:DisclosureForUnitOrDivisionOfTheCompany><in-capmkt:DisclosureForCommencementOfCommercialProductionOrCommercialOperationsOfTheCompany contextRef="MainI">Commercial operations</in-capmkt:DisclosureForCommencementOfCommercialProductionOrCommercialOperationsOfTheCompany><in-capmkt:NameOfUnitOrDivisionOfTheCompany contextRef="MainI">New Hospital Facility in Lucknow, Uttar Pradesh</in-capmkt:NameOfUnitOrDivisionOfTheCompany><in-capmkt:DateOfCommencement contextRef="MainI">2026-12-01</in-capmkt:DateOfCommencement><in-capmkt:DetailsOfCommencement contextRef="MainI">The commencement of commercial operations at the said Hospital Facility is now expected in December 2026, subject to completion of the requisite operational arrangements and readiness of the premises.</in-capmkt:DetailsOfCommencement><in-capmkt:WhetherPriorIntimationOfDateOfCommencementOfCommercialProductionOrOperationsWasGiven contextRef="MainI">true</in-capmkt:WhetherPriorIntimationOfDateOfCommencementOfCommercialProductionOrOperationsWasGiven><in-capmkt:DetailsOfPostponementOfTheDateOfCommencement contextRef="MainI">The commencement of operations at the Lucknow site has been delayed due to an increase in the scope of the Owner’s work, which has resulted in additional time being required for completion of the requisite site works and handover activities. The timeline has also been impacted by weather-related conditions at the site. Accordingly, the revised target date for commencement of operations at the Lucknow site is 1st December 2026.</in-capmkt:DetailsOfPostponementOfTheDateOfCommencement><in-capmkt:InitialDateOfIntimationForCommencement contextRef="MainI">2026-06-12</in-capmkt:InitialDateOfIntimationForCommencement><in-capmkt:TentativeDateOfCommencement contextRef="MainI">2026-12-01</in-capmkt:TentativeDateOfCommencement><in-capmkt:RemarksForWebsiteDisseminationForCommencementOrPostponementInTheDateOfCommencementOfCommercialProductionOrCommercialOperationsAsPerSubPara1OfParaB contextRef="MainI">With reference to the Company’s earlier intimation dated 12th June, 2026 regarding the establishment of a new Hospital Facility at Lucknow, Uttar Pradesh, wherein the commencement of commercial operations was earlier estimated for August 2026, the Company has received information today regarding the postponement of the said commencement timeline. Accordingly, the revised timeline is being intimated to the Stock Exchanges promptly upon receipt of the said information.</in-capmkt:RemarksForWebsiteDisseminationForCommencementOrPostponementInTheDateOfCommencementOfCommercialProductionOrCommercialOperationsAsPerSubPara1OfParaB></xbrli:xbrl>
