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<!--REG30PARAB V1.0 (01-06-2026)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Para_B_Of_Part_A_Of_Schedule_III/2026-04-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2026-04-30.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/NSESymbol">NEOGEN</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-10-30</xbrli:instant></xbrli:period></xbrli:context><in-capmkt:NSESymbol contextRef="MainI">NEOGEN</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">Neogen Chemicals Limited</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">542665</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE136S01016</in-capmkt:ISIN><in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">Disruption of operations (Sub-para 6-Para B)</in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">New</in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting contextRef="MainI">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainI">2026-10-29</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainI">14:50:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:DateOfReport contextRef="MainI">2026-10-30</in-capmkt:DateOfReport><in-capmkt:StageAtWhichDisruptionOfOperationsDisclosureIsProvided contextRef="MainI">Regularly, till complete normalcy is restored</in-capmkt:StageAtWhichDisruptionOfOperationsDisclosureIsProvided><in-capmkt:TypeOfDisruption contextRef="MainI">Fire</in-capmkt:TypeOfDisruption><in-capmkt:InsuranceAmountClaimedAndRealizedByTheListedEntityForTheLossOrDamage contextRef="MainI">The Company has conveyed its acceptance to the Insurance Company for an additional claim amount of Rs. 152.00 crore to be released in due course of time, as part payment out of the entire claim receivable. The total on- account claim received/ receivable including acceptance of this claim and sale of salvage scrap till date is Rs. 316.49 crore, with the further settlement to be determined in various stages following the completion of the assessment.</in-capmkt:InsuranceAmountClaimedAndRealizedByTheListedEntityForTheLossOrDamage><in-capmkt:ActualAmountOfDamageCausedDueToNaturalCalamityOrOtherForceMajeureEvents contextRef="MainI">The Company has recognised a loss of Rs 348.16 Crore (Rs. 362.90 Crore on consolidated basis) on account of damage to certain property, plant &amp; equipment, inventory and estimated cost of incidental charges. The Company has recognised an insurance claim receivable of Rs 334.60 Crore (Rs. 348.82 Crore on consolidated basis) to the extent of recovery of loss after adjusting applicable deductibility considering its assessment of loss and admissibility of claims as per the policy, adequacy of coverage and nature of loss. The Company has not accounted for a claim for loss of profit due to business interruption and excess value of reinstatement of assets over written down value as per accounting conservatism. The aforementioned losses and corresponding insurance claim have been considered on a net basis as Rs 13.56 Crore (Rs. 14.08 Crore on consolidated basis), in FY 2024-25. Till date the company has received Rs. 9.49 Crore on sale of salvaged scrap and incurred further incidental charges of Rs. 1.41 Crore which is also claimed as per insurance policy.</in-capmkt:ActualAmountOfDamageCausedDueToNaturalCalamityOrOtherForceMajeureEvents><in-capmkt:DetailsOfStepsTakenToRestoreNormalcyAndImpactOfTheNaturalCalamityOrOtherForceMajeureEventsOnProductionOrService contextRef="MainI">In continuation to our intimation dated April 23, 2025, we submit that the Production/Operation of the Multi-Purpose Plant (MPP3)- Facility, the warehouse and tank farms which were affected in fire is suspended temporarily. Construction of the replacement plant is partly completed, and trial runs have started in the completed portion of the facility.

In the interim, the Company has shifted production of critical select specialty products to other sites based on approval from customers. This, combined with the planned expansion in Patancheru Plant, will help minimize the impact on earnings going ahead to minimize business disruption.</in-capmkt:DetailsOfStepsTakenToRestoreNormalcyAndImpactOfTheNaturalCalamityOrOtherForceMajeureEventsOnProductionOrService></xbrli:xbrl>
