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<!--REG30PARAB V1.0 (01-06-2026)-->
<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Regulation_30_Para_B_Of_Part_A_Of_Schedule_III/2026-04-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2026-04-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2026-04-30.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">531349</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-29</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="I_AtTheTimeOfBecomingPartyToLitigationOrAssessmentOrAdjudicationOrArbitrationOrDispute"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">531349</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-29</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:explicitMember dimension="in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIIIAxis">in-capmkt:AtTheTimeOfBecomingPartyToLitigationOrAssessmentOrAdjudicationOrArbitrationOrDisputeMember</xbrldi:explicitMember></xbrli:scenario></xbrli:context><xbrli:context id="I_OppositePartyAsPerSubPara8OfParaB1"><xbrli:entity><xbrli:identifier scheme="http://www.sebi.gov.in/in-capmkt/ScripCode">531349</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-29</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:OppositePartyAsPerSubPara8OfParaBAxis"><in-capmkt:OppositePartyAsPerSubPara8OfParaBDomain>OppositePartyAsPerSubPara8OfParaBDomain1</in-capmkt:OppositePartyAsPerSubPara8OfParaBDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><in-capmkt:NSESymbol contextRef="MainI">PANACEABIO</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">Panacea Biotec Limited</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">531349</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE922B01023</in-capmkt:ISIN><in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">Pendency of any litigation(s) or dispute(s) (Sub-para 8-Para B)</in-capmkt:TypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="I_AtTheTimeOfBecomingPartyToLitigationOrAssessmentOrAdjudicationOrArbitrationOrDispute">At the time of becoming the party to any litigation, assessment, adjudication, arbitration or dispute</in-capmkt:SubTypeOfEventAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII contextRef="MainI">New</in-capmkt:TypeOfAnnouncementAsPerRegulation30ParaBOfPartAOfScheduleIII><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting contextRef="MainI">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfTheBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainI">2026-09-29</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainI">09:50:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:DateOfReport contextRef="MainI">2026-09-29</in-capmkt:DateOfReport><in-capmkt:NameOfOppositeParties contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Office of the Assistant Commissioner of Income Tax, Delhi</in-capmkt:NameOfOppositeParties><in-capmkt:DateOfInitiationOfLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">2026-09-28</in-capmkt:DateOfInitiationOfLitigation><in-capmkt:NameOfAuthorityWhereLitigationIsFiled contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Agency</in-capmkt:NameOfAuthorityWhereLitigationIsFiled><in-capmkt:DetailsOfAuthorityWhereLitigationIsFiled contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Office of the Assistant Commissioner of Income Tax, Delhi</in-capmkt:DetailsOfAuthorityWhereLitigationIsFiled><in-capmkt:PartyToTheLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Company</in-capmkt:PartyToTheLitigation><in-capmkt:DetailsOfPartyToTheLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Panacea Biotec Limited</in-capmkt:DetailsOfPartyToTheLitigation><in-capmkt:BriefDetailsOfLitigationOrDispute contextRef="I_OppositePartyAsPerSubPara8OfParaB1">The Company has received two Demand Orders from Office of the Assistant Commissioner of Income Tax, Delhi under the Income Tax Act, 1961 (“Act”) raising aggregate demand of ~₹4.32 Crore towards penalty on account of alleged misreporting / under reporting of income for Assessment Years 2022-23 and 2023-24.</in-capmkt:BriefDetailsOfLitigationOrDispute><in-capmkt:ExpectedFinancialImplicationsOfLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">Based on the Company’s assessment, the aforesaid demand is not maintainable, and the Company is taking all necessary steps including filing an Appeal with appellate authority against the said demand. The Company does not envisage any significant impact on financial, operation or other activities of the Company</in-capmkt:ExpectedFinancialImplicationsOfLitigation><in-capmkt:QuantumOfClaimsInLitigation contextRef="I_OppositePartyAsPerSubPara8OfParaB1">The department has alleged misreporting / under reporting of income in the assessment orders passed earlier and has imposed penalty of ~₹4.32 Crore under Section 270A of the Act</in-capmkt:QuantumOfClaimsInLitigation></xbrli:xbrl>
