<?xml version="1.0" encoding="UTF-8"?>
<xbrli:xbrl xmlns:in-capmkt="https://www.sebi.gov.in/xbrl/2023-05-31/in-capmkt" xmlns:in-capmkt-ent="https://www.sebi.gov.in/xbrl/Prior_Intimation_Of_Board_Meeting/2023-05-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="https://www.sebi.gov.in/xbrl/Prior_Intimation_Of_Board_Meeting/2023-05-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-type="https://www.sebi.gov.in/xbrl/2023-05-31/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink">
<link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2023-05-31.xsd"/>

<xbrli:unit id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><xbrli:unit id="shares"><xbrli:measure>xbrli:shares</xbrli:measure></xbrli:unit><xbrli:unit id="INRPerShare"><xbrli:divide><xbrli:unitNumerator><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unitNumerator><xbrli:unitDenominator><xbrli:measure>xbrli:shares</xbrli:measure></xbrli:unitDenominator></xbrli:divide></xbrli:unit>
<in-capmkt:NSESymbol contextRef="OneI">REMUS</in-capmkt:NSESymbol>
<in-capmkt:NameOfTheCompany contextRef="OneI">REMUS PHARMACEUTICALS LIMITED</in-capmkt:NameOfTheCompany>
<in-capmkt:ISIN contextRef="OneI">INE0O5T01011</in-capmkt:ISIN>
<in-capmkt:TypeOfMeeting contextRef="OneI">Board Meeting</in-capmkt:TypeOfMeeting>
<in-capmkt:TypeOfIntimation contextRef="OneD">New</in-capmkt:TypeOfIntimation>
<in-capmkt:DateOfProposedMeeting contextRef="OneD">2025-05-17</in-capmkt:DateOfProposedMeeting>
<in-capmkt:WhetherTradingWindowIsClosed contextRef="OneD">Yes</in-capmkt:WhetherTradingWindowIsClosed>
<in-capmkt:DateOfStartOfTradingWindowClosure contextRef="OneI">2025-04-01</in-capmkt:DateOfStartOfTradingWindowClosure>
<in-capmkt:DetailsOfDateOfEndOfTradingWindowClosure contextRef="OneI">2025-05-19</in-capmkt:DetailsOfDateOfEndOfTradingWindowClosure>
<in-capmkt:Agenda1 contextRef="OneD">Financial results</in-capmkt:Agenda1>
<in-capmkt:Agenda2 contextRef="OneD">Dividend</in-capmkt:Agenda2>
<in-capmkt:Agenda3 contextRef="OneD">Other business</in-capmkt:Agenda3>
<in-capmkt:WhetherResultsAreAuditedOrUnaudited contextRef="OneD">Audited</in-capmkt:WhetherResultsAreAuditedOrUnaudited>
<in-capmkt:NatureOfReportStandaloneConsolidated contextRef="OneD">Standalone And Consolidated</in-capmkt:NatureOfReportStandaloneConsolidated>
<in-capmkt:ReportingPeriodType contextRef="OneD">Yearly</in-capmkt:ReportingPeriodType>
<in-capmkt:MonthOfPeriodEnded contextRef="OneD">March</in-capmkt:MonthOfPeriodEnded>
<in-capmkt:YearOfPeriodEnded contextRef="OneI" unitRef="INR" decimals="0">2025</in-capmkt:YearOfPeriodEnded>
<in-capmkt:TypeOfDividend contextRef="OneD">Final</in-capmkt:TypeOfDividend>
<in-capmkt:RemarksWebsiteDissemination contextRef="OneI">Further, in this connection, please refer our earlier intimation dated March 27, 2025, whereby, pursuant to the Company’s Code of Conduct framed in accordance with the Securities and Exchange Board of India (Prohibition of Insider Trading) Regulations, 2015 as amended (“the Code”), the Trading Window for dealing in securities of the Company, for persons specified under the Code, was closed from April 01, 2025 till 48 hours after the Audited Standalone and Consolidated Financial Results of the Company for the half year and financial year March 31, 2025 are approved by the Board of Directors and submitted to Stock Exchange.</in-capmkt:RemarksWebsiteDissemination>
</xbrli:xbrl>