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<!--OBM V1.0 (01-01-2026)-->
<xbrli:xbrl xmlns:in-capmkt="https://www.sebi.gov.in/xbrl/2024-05-31/in-capmkt" xmlns:in-capmkt-roles="https://www.sebi.gov.in/xbrl/Announcements_Pertaining_To_Outcome_Of_Board_Meeting/2024-05-31/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="https://www.sebi.gov.in/xbrl/2024-05-31/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2024-05-31.xsd"/><xbrli:context id="MainD"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">532926</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-11-04</xbrli:startDate><xbrli:endDate>2026-11-04</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">532926</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-11-04</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="BuybackD"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">532926</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-11-04</xbrli:startDate><xbrli:endDate>2026-11-04</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="BuybackI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">532926</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-11-04</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="PreI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">532926</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-11-04</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="PostI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">532926</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-11-04</xbrli:instant></xbrli:period></xbrli:context><xbrli:unit id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><xbrli:unit id="shares"><xbrli:measure>xbrli:shares</xbrli:measure></xbrli:unit><xbrli:unit id="INRPerShare"><xbrli:divide><xbrli:unitNumerator><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unitNumerator><xbrli:unitDenominator><xbrli:measure>xbrli:shares</xbrli:measure></xbrli:unitDenominator></xbrli:divide></xbrli:unit><in-capmkt:NSESymbol contextRef="MainI">JYOTHYLAB</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">JYOTHY LABS LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:TypeOfAnnouncementOfBoardMeeting contextRef="MainD">New</in-capmkt:TypeOfAnnouncementOfBoardMeeting><in-capmkt:FirstEventOfBoardMeeting contextRef="MainD">Buy-back</in-capmkt:FirstEventOfBoardMeeting><in-capmkt:DateOfReport contextRef="MainI">2026-11-04</in-capmkt:DateOfReport><in-capmkt:TypeOfSecuritiesOfBuyback contextRef="BuybackD">Equity</in-capmkt:TypeOfSecuritiesOfBuyback><in-capmkt:DateOfBoardMeetingToConsiderTheDecisionOnBuybackOfSecurities contextRef="BuybackI">2026-11-04</in-capmkt:DateOfBoardMeetingToConsiderTheDecisionOnBuybackOfSecurities><in-capmkt:StartTimeOfBoardMeetingForAnnouncementOfBuyback contextRef="BuybackD">11:00:00</in-capmkt:StartTimeOfBoardMeetingForAnnouncementOfBuyback><in-capmkt:EndTimeOfBoardMeetingForAnnouncementOfBuyback contextRef="BuybackD">13:40:00</in-capmkt:EndTimeOfBoardMeetingForAnnouncementOfBuyback><in-capmkt:WhetherPriorIntimationOfBoardMeetingForConsideringBuybackOfSecuritiesFiledWithTheExchange contextRef="BuybackI">true</in-capmkt:WhetherPriorIntimationOfBoardMeetingForConsideringBuybackOfSecuritiesFiledWithTheExchange><in-capmkt:DateOfPriorIntimationSubmittedToStockExchangeOnBoardMeetingForConsideringBuybackOfSecuritiesFiledWithTheExchange contextRef="BuybackI">2026-10-30</in-capmkt:DateOfPriorIntimationSubmittedToStockExchangeOnBoardMeetingForConsideringBuybackOfSecuritiesFiledWithTheExchange><in-capmkt:WhetherDecisionOnBuybackOfSecuritiesApprovedByTheBoard contextRef="BuybackD">Yes</in-capmkt:WhetherDecisionOnBuybackOfSecuritiesApprovedByTheBoard><in-capmkt:WhetherBuybackIsLessThanOrEqualToTenPercentOfTheTotalPaidUpEquityCapitalAndFreeReservesOfTheCompany contextRef="BuybackI">true</in-capmkt:WhetherBuybackIsLessThanOrEqualToTenPercentOfTheTotalPaidUpEquityCapitalAndFreeReservesOfTheCompany><in-capmkt:WhetherAnyRecordDateOrBookClosureDateIntimatedEarlierForBuyback contextRef="BuybackI">true</in-capmkt:WhetherAnyRecordDateOrBookClosureDateIntimatedEarlierForBuyback><in-capmkt:IntimationDateOfRecordOrBookClosureDate contextRef="BuybackI">2026-11-04</in-capmkt:IntimationDateOfRecordOrBookClosureDate><in-capmkt:WhetherTheModeOrQuantumOrPricingOrTimingAndOtherDetailsOfBuybackDecidedByTheBoard contextRef="BuybackI">true</in-capmkt:WhetherTheModeOrQuantumOrPricingOrTimingAndOtherDetailsOfBuybackDecidedByTheBoard><in-capmkt:WhetherRecordDateOrBookClosureDateIsFixedByTheCompanyForBuyback contextRef="BuybackI">true</in-capmkt:WhetherRecordDateOrBookClosureDateIsFixedByTheCompanyForBuyback><in-capmkt:RecordDateOrBookClosureDateForBuyback contextRef="BuybackD">Record Date</in-capmkt:RecordDateOrBookClosureDateForBuyback><in-capmkt:RecordDateOfBuyback contextRef="BuybackI">2026-11-11</in-capmkt:RecordDateOfBuyback><in-capmkt:MethodsOfBuyback contextRef="BuybackD">Tender Offer</in-capmkt:MethodsOfBuyback><in-capmkt:MaximumBuybackSizeApprovedByBoardOfDirectors contextRef="BuybackI" unitRef="INR" decimals="0">1470000150</in-capmkt:MaximumBuybackSizeApprovedByBoardOfDirectors><in-capmkt:NumberOfSecuritiesProposedForBuyback contextRef="BuybackI" unitRef="shares" decimals="INF">6837210</in-capmkt:NumberOfSecuritiesProposedForBuyback><in-capmkt:NumberOfSecuritiesProposedForBuybackAsAPercentageOfExistingPaidUpCapital contextRef="BuybackI" unitRef="shares" decimals="INF">2</in-capmkt:NumberOfSecuritiesProposedForBuybackAsAPercentageOfExistingPaidUpCapital><in-capmkt:BuybackPrice contextRef="BuybackD" unitRef="INRPerShare" decimals="INF">215</in-capmkt:BuybackPrice><in-capmkt:NumberOfActualSecuritiesInOfExistingPaidUpCapitalBoughtBack contextRef="BuybackI" unitRef="shares" decimals="INF">0</in-capmkt:NumberOfActualSecuritiesInOfExistingPaidUpCapitalBoughtBack><in-capmkt:PercentageOfActualSecuritiesOfExistingPaidUpCapitalBoughtBack contextRef="BuybackI" unitRef="pure" decimals="INF">0</in-capmkt:PercentageOfActualSecuritiesOfExistingPaidUpCapitalBoughtBack><in-capmkt:ConfirmThatTheBuybackUndertakenIsNotWithinAPeriodOfOneYearFromTheDateOfExpiryOfBuybackPeriodOfThePrecedingOfferOfBuyback contextRef="BuybackD">Not Applicable</in-capmkt:ConfirmThatTheBuybackUndertakenIsNotWithinAPeriodOfOneYearFromTheDateOfExpiryOfBuybackPeriodOfThePrecedingOfferOfBuyback><in-capmkt:NotesForBuybackUndertakenWithinAPeriodOfOneYearFromTheDateOfExpiryOfBuybackPeriodOfThePrecedingOfferOfBuyback contextRef="BuybackI">The Company has not done any Buyback in the past</in-capmkt:NotesForBuybackUndertakenWithinAPeriodOfOneYearFromTheDateOfExpiryOfBuybackPeriodOfThePrecedingOfferOfBuyback><in-capmkt:ConfirmThatNumberOfSharesOrOtherSpecifiedSecuritiesAreIssuedDuringTheBuybackPeriod contextRef="BuybackD">Yes</in-capmkt:ConfirmThatNumberOfSharesOrOtherSpecifiedSecuritiesAreIssuedDuringTheBuybackPeriod><in-capmkt:RemarksForWebsiteDisseminationForBuybackEvent contextRef="BuybackI">The approved buyback is up to 68,37,210 fully paid-up equity shares of the Company, having face value of Re.1/- each ("Equity Shares"), representing 1.86 % of the total number of equity shares in the total paid-up equity share capital of the Company as at March 31, 2026. However as the XBRL utility is only taking a whole number, we have mentioned it as 2%.</in-capmkt:RemarksForWebsiteDisseminationForBuybackEvent><in-capmkt:PreBuybackNumberOfSharesUnderPromoterAndPromoterGroupCategory contextRef="PreI" unitRef="shares" decimals="INF">230934685</in-capmkt:PreBuybackNumberOfSharesUnderPromoterAndPromoterGroupCategory><in-capmkt:PreBuybackPercentageForPromoterAndPromoterGroupCategoryOfExistingShareCapital contextRef="PreI" unitRef="pure" decimals="INF">0.6288</in-capmkt:PreBuybackPercentageForPromoterAndPromoterGroupCategoryOfExistingShareCapital><in-capmkt:PreBuybackNumberOfSharesUnderPublicCategory contextRef="PreI" unitRef="shares" decimals="INF">136300835</in-capmkt:PreBuybackNumberOfSharesUnderPublicCategory><in-capmkt:PreBuybackPercentageForPublicCategoryOfExistingShareCapital contextRef="PreI" unitRef="pure" decimals="INF">0.3712</in-capmkt:PreBuybackPercentageForPublicCategoryOfExistingShareCapital><in-capmkt:PreBuybackNumberOfSharesUnderOtherCategory contextRef="PreI" unitRef="shares" decimals="INF">0</in-capmkt:PreBuybackNumberOfSharesUnderOtherCategory><in-capmkt:PreBuybackPercentageForOtherCategoryOfExistingShareCapital contextRef="PreI" unitRef="pure" decimals="INF">0</in-capmkt:PreBuybackPercentageForOtherCategoryOfExistingShareCapital><in-capmkt:PreBuybackNumberOfShares contextRef="PreI" unitRef="shares" decimals="INF">367235520</in-capmkt:PreBuybackNumberOfShares><in-capmkt:PreBuybackPercentageForTotalBuybackOfExistingShareCapital contextRef="PreI" unitRef="pure" decimals="INF">1</in-capmkt:PreBuybackPercentageForTotalBuybackOfExistingShareCapital><in-capmkt:WhetherPostBuybackShareholdingPatternAvailable contextRef="PostI">false</in-capmkt:WhetherPostBuybackShareholdingPatternAvailable><in-capmkt:NotesForUnAvailabilityOfPostBuybackShareholdingDetails contextRef="PostI">The post-buyback shareholding pattern of the Company shall be ascertained subsequently</in-capmkt:NotesForUnAvailabilityOfPostBuybackShareholdingDetails></xbrli:xbrl>
