<?xml version="1.0" encoding="UTF-8"?>
<!--NOS V1.0 (10-04-2026)-->
<xbrli:xbrl xmlns:in-capmkt="https://www.sebi.gov.in/xbrl/2024-05-31/in-capmkt" xmlns:in-capmkt-ent="https://www.sebi.gov.in/xbrl/Notice_Of_Shareholders_Meeting/2024-05-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="https://www.sebi.gov.in/xbrl/Notice_Of_Shareholders_Meeting/2024-05-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2024-05-31.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="D_DetailofResolution1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain1</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain1</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_DetailofResolution2"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain2</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution2"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain2</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_DetailofResolution3"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain3</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution3"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain3</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_DetailofResolution4"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain4</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution4"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain4</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_DetailofResolution5"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain5</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution5"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain5</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_DetailofResolution6"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain6</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution6"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain6</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_DetailofResolution7"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain7</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution7"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain7</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_DetailofResolution8"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-08-01</xbrli:startDate><xbrli:endDate>2026-08-01</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain8</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution8"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">508869</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-08-01</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain8</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:unit id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><in-capmkt:NameOfTheCompany contextRef="MainI">APOLLO HOSPITALS ENTERPRISE LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:NSESymbol contextRef="MainI">APOLLOHOSP</in-capmkt:NSESymbol><in-capmkt:TypeOfAnnouncement contextRef="MainI">New</in-capmkt:TypeOfAnnouncement><in-capmkt:DateOfOccurrenceOfEvent contextRef="MainI">2026-08-25</in-capmkt:DateOfOccurrenceOfEvent><in-capmkt:TimeOfOccurrenceOfEvent contextRef="MainI">10:15:00</in-capmkt:TimeOfOccurrenceOfEvent><in-capmkt:DateOfReport contextRef="MainI">2026-08-01</in-capmkt:DateOfReport><in-capmkt:EventForNoticeOfShareholdersMeeting contextRef="MainI">Annual General Meeting</in-capmkt:EventForNoticeOfShareholdersMeeting><in-capmkt:ModeOfShareholdersMeeting contextRef="MainI">Video Conference (VC) or Other Audio-Visual Means (OAVM)</in-capmkt:ModeOfShareholdersMeeting><in-capmkt:NumberOfShareholdersMeeting contextRef="MainI">1</in-capmkt:NumberOfShareholdersMeeting><in-capmkt:DayOfShareholdersMeeting contextRef="MainI">Tuesday</in-capmkt:DayOfShareholdersMeeting><in-capmkt:DateOfShareholdersMeeting contextRef="MainI">2026-08-25</in-capmkt:DateOfShareholdersMeeting><in-capmkt:ShareholdersMeetingCommencementTime contextRef="MainI">10:15:00</in-capmkt:ShareholdersMeetingCommencementTime><in-capmkt:PlaceOfShareholdersMeeting contextRef="MainI">chennai</in-capmkt:PlaceOfShareholdersMeeting><in-capmkt:NumberOfAgendaOrBusinessToBeTransacted contextRef="MainI" unitRef="pure" decimals="0">8</in-capmkt:NumberOfAgendaOrBusinessToBeTransacted><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution1">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution1">Adoption of Financial Statements</in-capmkt:CategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution1">Adoption of standalone and consolidated financial statements of the Company for the year ended March 31 2026</in-capmkt:BriefDetailsOfResolution><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution2">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution2">Others</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution2">Others</in-capmkt:SubCategoryOfResolution><in-capmkt:DetailsOfOtherSubCategoryOfResolution contextRef="D_DetailofResolution2">Dividend</in-capmkt:DetailsOfOtherSubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution2">Confirmation of Interim Dividend and approval of declaration of final dividend</in-capmkt:BriefDetailsOfResolution><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution3">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution3">Appointment/Re-appointment/Removal/Ratification/Retirement/Remuneration</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution3">Retirement by rotation</in-capmkt:SubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution3">Re-appointment of Ms. Sangita Reddy who retires by rotation and being eligble offers herself for re-appointment</in-capmkt:BriefDetailsOfResolution><in-capmkt:DesignationOfDesignatedPerson contextRef="I_DetailofResolution3">Non-Executive - Non-Independent Director</in-capmkt:DesignationOfDesignatedPerson><in-capmkt:NameOfDesignatedPerson contextRef="D_DetailofResolution3">Sangita Reddy</in-capmkt:NameOfDesignatedPerson><in-capmkt:DirectorIdentificationNumberOfDirector contextRef="D_DetailofResolution3">00006285</in-capmkt:DirectorIdentificationNumberOfDirector><in-capmkt:DateOfStartOfTenure contextRef="D_DetailofResolution3">2026-06-25</in-capmkt:DateOfStartOfTenure><in-capmkt:DateOfEndOfTenure contextRef="D_DetailofResolution3">2029-06-25</in-capmkt:DateOfEndOfTenure><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution4">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution4">Appointment/Re-appointment/Removal/Ratification/Retirement/Remuneration</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution4">Retirement by rotation</in-capmkt:SubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution4">Re-appointment of Dr. Prathap C Reddy who retires by rotation and being eligble offers himself for re-appointment</in-capmkt:BriefDetailsOfResolution><in-capmkt:DesignationOfDesignatedPerson contextRef="I_DetailofResolution4">Non-Executive - Non-Independent Director</in-capmkt:DesignationOfDesignatedPerson><in-capmkt:NameOfDesignatedPerson contextRef="D_DetailofResolution4">Dr. Prathap C Reddy</in-capmkt:NameOfDesignatedPerson><in-capmkt:DirectorIdentificationNumberOfDirector contextRef="D_DetailofResolution4">00003654</in-capmkt:DirectorIdentificationNumberOfDirector><in-capmkt:DateOfStartOfTenure contextRef="D_DetailofResolution4">2026-06-25</in-capmkt:DateOfStartOfTenure><in-capmkt:DateOfEndOfTenure contextRef="D_DetailofResolution4">2029-06-25</in-capmkt:DateOfEndOfTenure><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution5">Special Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution5">Appointment/Re-appointment/Removal/Ratification/Retirement/Remuneration</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution5">Re-appointment</in-capmkt:SubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution5">Approval for Re-appointment of Dr. Prathap C Reddy 
(DIN: 00003654) as Executive Chairman  for a further
period of two years.</in-capmkt:BriefDetailsOfResolution><in-capmkt:DesignationOfDesignatedPerson contextRef="I_DetailofResolution5">Executive Director</in-capmkt:DesignationOfDesignatedPerson><in-capmkt:NameOfDesignatedPerson contextRef="D_DetailofResolution5">Dr. Prathap C Reddy</in-capmkt:NameOfDesignatedPerson><in-capmkt:DirectorIdentificationNumberOfDirector contextRef="D_DetailofResolution5">00003654</in-capmkt:DirectorIdentificationNumberOfDirector><in-capmkt:DateOfStartOfTenure contextRef="D_DetailofResolution5">2026-06-25</in-capmkt:DateOfStartOfTenure><in-capmkt:DateOfEndOfTenure contextRef="D_DetailofResolution5">2028-06-24</in-capmkt:DateOfEndOfTenure><in-capmkt:NumberOfTimesAppointed contextRef="D_DetailofResolution5" unitRef="pure" decimals="0">7</in-capmkt:NumberOfTimesAppointed><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution6">Special Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution6">Appointment/Re-appointment/Removal/Ratification/Retirement/Remuneration</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution6">Re-appointment</in-capmkt:SubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution6">Approval for Re-appointment of Smt. Rama Bijapurkar
(DIN: 00001835) as an Independent Director of the
Company.</in-capmkt:BriefDetailsOfResolution><in-capmkt:DesignationOfDesignatedPerson contextRef="I_DetailofResolution6">Non-Executive - Independent Director</in-capmkt:DesignationOfDesignatedPerson><in-capmkt:NameOfDesignatedPerson contextRef="D_DetailofResolution6">Rama Bijapurkar</in-capmkt:NameOfDesignatedPerson><in-capmkt:DirectorIdentificationNumberOfDirector contextRef="D_DetailofResolution6">00001835</in-capmkt:DirectorIdentificationNumberOfDirector><in-capmkt:DateOfStartOfTenure contextRef="D_DetailofResolution6">2026-11-12</in-capmkt:DateOfStartOfTenure><in-capmkt:DateOfEndOfTenure contextRef="D_DetailofResolution6">2031-11-11</in-capmkt:DateOfEndOfTenure><in-capmkt:NumberOfTimesAppointed contextRef="D_DetailofResolution6" unitRef="pure" decimals="0">1</in-capmkt:NumberOfTimesAppointed><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution7">Special Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution7">Issuance/Corporate Action</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution7">Issuance of Securities</in-capmkt:SubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution7">Issuance of Non-Convertible Debentures on a Private
Placement Basis for a sum upto Rs.7,500 million</in-capmkt:BriefDetailsOfResolution><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution8">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution8">Appointment/Re-appointment/Removal/Ratification/Retirement/Remuneration</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution8">Remuneration</in-capmkt:SubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution8">Ratification of the Remuneration Payable to the Cost
Auditor.</in-capmkt:BriefDetailsOfResolution><in-capmkt:DesignationOfDesignatedPerson contextRef="I_DetailofResolution8">Others</in-capmkt:DesignationOfDesignatedPerson><in-capmkt:DetailsOfOtherDesignation contextRef="D_DetailofResolution8">Remuneration Payable to the Cost
Auditor</in-capmkt:DetailsOfOtherDesignation><in-capmkt:NameOfDesignatedPerson contextRef="D_DetailofResolution8">AN Raman &amp; Associates</in-capmkt:NameOfDesignatedPerson><in-capmkt:DateOfStartOfTenure contextRef="D_DetailofResolution8">2026-04-01</in-capmkt:DateOfStartOfTenure><in-capmkt:DateOfEndOfTenure contextRef="D_DetailofResolution8">2027-03-31</in-capmkt:DateOfEndOfTenure><in-capmkt:AmountOfRemuneration contextRef="D_DetailofResolution8" unitRef="INR" decimals="0">1650000</in-capmkt:AmountOfRemuneration></xbrli:xbrl>
