<?xml version="1.0" encoding="UTF-8" standalone="no"?><xbrli:xbrl xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:in-capmkt="https://www.sebi.gov.in/xbrl/2024-05-31/in-capmkt" xmlns:in-capmkt-ent="https://www.sebi.gov.in/xbrl/Notice_Of_Shareholders_Meeting/2024-05-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="https://www.sebi.gov.in/xbrl/Notice_Of_Shareholders_Meeting/2024-05-31/in-capmkt-roles" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:xlink="http://www.w3.org/1999/xlink"><link:schemaRef xlink:href="in-capmkt-ent-2024-05-31.xsd" xlink:type="simple"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">524372</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2025-05-25</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="D_DetailofResolution1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">524372</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2025-05-25</xbrli:startDate><xbrli:endDate>2025-05-25</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain1</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="I_DetailofResolution1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/ScripCode">524372</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2025-05-25</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ResolutionOrAgendaAxis"><in-capmkt:ResolutionOrAgendaDomain>ResolutionOrAgendaDomain1</in-capmkt:ResolutionOrAgendaDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><in-capmkt:NameOfTheCompany contextRef="MainI">Orchid Pharma Limited</in-capmkt:NameOfTheCompany><in-capmkt:NSESymbol contextRef="MainI">ORCHPHARMA</in-capmkt:NSESymbol><in-capmkt:TypeOfAnnouncement contextRef="MainI">New</in-capmkt:TypeOfAnnouncement><in-capmkt:DateOfOccurrenceOfEvent contextRef="MainI">2025-05-24</in-capmkt:DateOfOccurrenceOfEvent><in-capmkt:TimeOfOccurrenceOfEvent contextRef="MainI">18:22:00</in-capmkt:TimeOfOccurrenceOfEvent><in-capmkt:RemarksForWebsiteDissemination contextRef="MainI">Notice of Meeting of Equity Shareholders of Orchid Pharma Limited scheduled to be held through Video Conferencing / Other Audio-Visual Means (“VC”/“OAVM”) pursuant to the order dated April 29, 2025, read with revised order dated May 9, 2025,, passed by the Hon’ble National Company Law Tribunal, Division Bench – II, Chennai.</in-capmkt:RemarksForWebsiteDissemination><in-capmkt:EventForNoticeOfShareholdersMeeting contextRef="MainI">NCLT/ Court Convened Meeting</in-capmkt:EventForNoticeOfShareholdersMeeting><in-capmkt:ModeOfShareholdersMeeting contextRef="MainI">Video Conference (VC) or Other Audio-Visual Means (OAVM)</in-capmkt:ModeOfShareholdersMeeting><in-capmkt:NumberOfShareholdersMeeting contextRef="MainI">1</in-capmkt:NumberOfShareholdersMeeting><in-capmkt:DayOfShareholdersMeeting contextRef="MainI">Thursday</in-capmkt:DayOfShareholdersMeeting><in-capmkt:DateOfShareholdersMeeting contextRef="MainI">2025-06-26</in-capmkt:DateOfShareholdersMeeting><in-capmkt:ShareholdersMeetingCommencementTime contextRef="MainI">12:30:00</in-capmkt:ShareholdersMeetingCommencementTime><in-capmkt:PlaceOfShareholdersMeeting contextRef="MainI">NA</in-capmkt:PlaceOfShareholdersMeeting><in-capmkt:NumberOfAgendaOrBusinessToBeTransacted contextRef="MainI" decimals="0" unitRef="pure">1</in-capmkt:NumberOfAgendaOrBusinessToBeTransacted><in-capmkt:OtherInformationForShareholdersMeeting contextRef="MainI">Cut off Date for E-Voting is June 19, 2025. &lt;BR&gt; 
 &lt;BR&gt; 
Evoting Period is from June 23, 2025, 10:00 A.M. to June 25, 2025 till 05:00 P.M.</in-capmkt:OtherInformationForShareholdersMeeting><in-capmkt:RemarksForWebsiteDisseminationForShareholdersMeeting contextRef="MainI">Notice of Meeting of Equity Shareholders of Orchid Pharma Limited scheduled to be held through Video Conferencing / Other Audio-Visual Means (“VC”/“OAVM”) pursuant to the order dated April 29, 2025, read with revised order dated May 9, 2025,, passed by the Hon’ble National Company Law Tribunal, Division Bench – II, Chennai.</in-capmkt:RemarksForWebsiteDisseminationForShareholdersMeeting><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution1">Special Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution1">Restructuring/Scheme of Arrangement/Loans</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution1">Scheme of Arrangement</in-capmkt:SubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution1">To consider and, if
thought fit, approve, with or without modification, the proposed Scheme of Amalgamation
and Arrangement of Dhanuka Laboratories Limited with Orchid Pharma Limited and their
respective shareholders and creditors</in-capmkt:BriefDetailsOfResolution></xbrli:xbrl>