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<xbrli:xbrl xmlns:in-capmkt="https://www.sebi.gov.in/xbrl/2024-05-31/in-capmkt" xmlns:in-capmkt-ent="https://www.sebi.gov.in/xbrl/Notice_Of_Shareholders_Meeting/2024-05-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="https://www.sebi.gov.in/xbrl/Notice_Of_Shareholders_Meeting/2024-05-31/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2024-05-31.xsd"/><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier 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id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><in-capmkt:NSESymbol contextRef="MainI">BIOFILCHEM</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">BIOFIL CHEMICALS &amp; PHARMACEUTICALS LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:TypeOfAnnouncement contextRef="MainI">New</in-capmkt:TypeOfAnnouncement><in-capmkt:DateOfOccurrenceOfEvent contextRef="MainI">2026-08-26</in-capmkt:DateOfOccurrenceOfEvent><in-capmkt:TimeOfOccurrenceOfEvent contextRef="MainI">16:29:00</in-capmkt:TimeOfOccurrenceOfEvent><in-capmkt:DateOfReport contextRef="MainI">2026-08-26</in-capmkt:DateOfReport><in-capmkt:EventForNoticeOfShareholdersMeeting contextRef="MainI">Annual General Meeting</in-capmkt:EventForNoticeOfShareholdersMeeting><in-capmkt:ModeOfShareholdersMeeting contextRef="MainI">Video Conference (VC) or Other Audio-Visual Means (OAVM)</in-capmkt:ModeOfShareholdersMeeting><in-capmkt:NumberOfShareholdersMeeting contextRef="MainI">41</in-capmkt:NumberOfShareholdersMeeting><in-capmkt:DayOfShareholdersMeeting contextRef="MainI">Wednesday</in-capmkt:DayOfShareholdersMeeting><in-capmkt:DateOfShareholdersMeeting contextRef="MainI">2026-09-23</in-capmkt:DateOfShareholdersMeeting><in-capmkt:ShareholdersMeetingCommencementTime contextRef="MainI">15:00:00</in-capmkt:ShareholdersMeetingCommencementTime><in-capmkt:PlaceOfShareholdersMeeting contextRef="MainI">Indore</in-capmkt:PlaceOfShareholdersMeeting><in-capmkt:NumberOfAgendaOrBusinessToBeTransacted contextRef="MainI" unitRef="pure" decimals="0">4</in-capmkt:NumberOfAgendaOrBusinessToBeTransacted><in-capmkt:NameOfListedEntityOrSubsidiaryEnteringIntoTheTransaction contextRef="D_DetailofRPT1">BIOFIL CHEMICALS &amp; PHARMACEUTICALS LIMITED</in-capmkt:NameOfListedEntityOrSubsidiaryEnteringIntoTheTransaction><in-capmkt:NameOfCounterParty contextRef="D_DetailofRPT1">Cyano Pharma Private Limited</in-capmkt:NameOfCounterParty><in-capmkt:RelationshipOfTheCounterpartyWithTheListedEntityOrItsSubsidiary contextRef="D_DetailofRPT1">Mr. Ketan Shah, Chairman and Managing Director of the Company and Shri Smitesh Shah Non-Executive Non-Independent Director alongwith their respective relatives are shareholders/members of Cyano Pharma Private Limited</in-capmkt:RelationshipOfTheCounterpartyWithTheListedEntityOrItsSubsidiary><in-capmkt:TypeOfRelatedPartyTransaction contextRef="D_DetailofRPT1">Any other transaction</in-capmkt:TypeOfRelatedPartyTransaction><in-capmkt:DetailsOfOtherRelatedPartyTransaction contextRef="D_DetailofRPT1">Purchase and Sale of goods and Rendering of services (job work), and other similar business transactions including transfer of resources, services</in-capmkt:DetailsOfOtherRelatedPartyTransaction><in-capmkt:AmountOfRelatedPartyTransactionDuringTheReportingPeriod contextRef="D_DetailofRPT1" unitRef="INR" decimals="0">200000000</in-capmkt:AmountOfRelatedPartyTransactionDuringTheReportingPeriod><in-capmkt:DateOfStartOfTenure contextRef="D_DetailofRPT1">2026-04-01</in-capmkt:DateOfStartOfTenure><in-capmkt:DateOfEndOfTenure contextRef="D_DetailofRPT1">2027-09-30</in-capmkt:DateOfEndOfTenure><in-capmkt:RemarksForTenureOfTheRelatedPartyTransaction contextRef="D_DetailofRPT1">Aggregate value of up to 20 Crores to be entered for financial year 2026-27 and up to the date of 42nd Annual General Meeting</in-capmkt:RemarksForTenureOfTheRelatedPartyTransaction><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution1">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution1">Adoption of Financial Statements</in-capmkt:CategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution1">To consider and adopt the Audited Financial Statements of the Company together with the Report of the Board of Directors and the Auditors thereon for the financial year ended March 31, 2026.</in-capmkt:BriefDetailsOfResolution><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution2">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution2">Others</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution2">Others</in-capmkt:SubCategoryOfResolution><in-capmkt:DetailsOfOtherSubCategoryOfResolution contextRef="D_DetailofResolution2">Retire by rotation</in-capmkt:DetailsOfOtherSubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution2">To appoint a Director in place of Mr. Smitesh Shah (DIN: 00326182) who retires by rotation in terms of Section 152(6) of the Companies Act, 2013 and being eligible offers himself for re-appointment.</in-capmkt:BriefDetailsOfResolution><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution3">Special Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution3">Others</in-capmkt:CategoryOfResolution><in-capmkt:SubCategoryOfResolution contextRef="I_DetailofResolution3">Others</in-capmkt:SubCategoryOfResolution><in-capmkt:DetailsOfOtherSubCategoryOfResolution contextRef="D_DetailofResolution3">Continuation of directorship as a Non-Executive Independent Director on attaining the age of 75 (seventy-five) years.</in-capmkt:DetailsOfOtherSubCategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution3">Continuation of directorship of Mr. Ashok Kumar Ramawat (DIN: 08818263) as a Non-Executive Independent Director of the Company on attaining the age of 75 (seventy-five) years.</in-capmkt:BriefDetailsOfResolution><in-capmkt:TypeOfResolution contextRef="I_DetailofResolution4">Ordinary Resolution</in-capmkt:TypeOfResolution><in-capmkt:CategoryOfResolution contextRef="I_DetailofResolution4">Related Party Transaction</in-capmkt:CategoryOfResolution><in-capmkt:BriefDetailsOfResolution contextRef="D_DetailofResolution4">Approval of Material Related Party Transaction(s) with Cyano Pharma Private Limited.</in-capmkt:BriefDetailsOfResolution></xbrli:xbrl>
