<?xml version="1.0" encoding="UTF-8" standalone="no"?><!--IFFIndAs--><xbrli:xbrl xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-01-31/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/IntegratedFinance_IndAS/2025-01-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="http://www.sebi.gov.in/xbrl/IntegratedFinance_IndAS/2025-01-31/in-capmkt-roles" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2025-01-31/in-capmkt-types" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:xlink="http://www.w3.org/1999/xlink"><link:schemaRef 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unitRef="INRPerShare">6.69</in-capmkt:DilutedEarningsLossPerShareFromContinuingOperations><in-capmkt:BasicEarningsLossPerShareFromDiscontinuedOperations contextRef="OneD" decimals="INF" unitRef="INRPerShare">0</in-capmkt:BasicEarningsLossPerShareFromDiscontinuedOperations><in-capmkt:DilutedEarningsLossPerShareFromDiscontinuedOperations contextRef="OneD" decimals="INF" unitRef="INRPerShare">0</in-capmkt:DilutedEarningsLossPerShareFromDiscontinuedOperations><in-capmkt:BasicEarningsLossPerShareFromContinuingAndDiscontinuedOperations contextRef="OneD" decimals="INF" unitRef="INRPerShare">6.69</in-capmkt:BasicEarningsLossPerShareFromContinuingAndDiscontinuedOperations><in-capmkt:DilutedEarningsLossPerShareFromContinuingAndDiscontinuedOperations contextRef="OneD" decimals="INF" unitRef="INRPerShare">6.69</in-capmkt:DilutedEarningsLossPerShareFromContinuingAndDiscontinuedOperations><in-capmkt:DisclosureOfNotesOnFinancialResultsExplanatoryTextBlock contextRef="OneD">1. The unaudited consolidated financial results of Jupiter Life Line Hospitals Limited ('the Company') and its subsidiaries (together referred to as “the Group”)  for the quarter ended June 30, 2025 have been reviewed by the Audit Committee and approved by the Board of Directors at their respective meetings held on August 1, 2025. These results have been subjected to limited review by the joint statutory auditors of the Company, M/s. Aswin P. Malde &amp; Co and M/s. KKC &amp; Associates LLP, who have issued an unmodified limited review report. &lt;BR&gt; 
 &lt;BR&gt; 
2. These consolidated financial results have been prepared in accordance with the recognition and measurement principles laid down in Indian Accounting Standard (Ind AS) 34 - Interim Financial Reporting, as prescribed under Section 133 of the Companies Act, 2013, read with the relevant rules issued thereunder, and in compliance with the requirements of Regulation 33 of the SEBI (Listing Obligations and Disclosure Requirements) Regulations, 2015, and other accounting principles generally accepted in India. &lt;BR&gt; 
 &lt;BR&gt; 
3. The Company in respect of non-corporate entities (i.e., partnership firms), consolidates its share of net profit or loss and recognises the same on net income basis in the consolidated Statement of Profit and Loss. &lt;BR&gt; 
 &lt;BR&gt; 
The details of such entities is as under: &lt;BR&gt; 
 &lt;BR&gt; 
Name of the Entity	Country of Incorporation	Proportion of ownership interest &lt;BR&gt; 
Jupiter Pharmacy*  &lt;BR&gt; 
(till conversion date)	India	                         95.00% &lt;BR&gt; 
Katyayini Hospitality	India	                         95.00% &lt;BR&gt; 
Jupiter Gait Lab	                India	                         51.00% &lt;BR&gt; 
Mangleshwar Hospitality 	India	                         95.00% &lt;BR&gt; 
(held through Jupiter Hospital Projects Private Limited) &lt;BR&gt; 
Vishesh Jupiter Pharmacy 	India	                         95.00% &lt;BR&gt; 
(held through Jupiter Hospital Projects Private Limited) &lt;BR&gt; 
 &lt;BR&gt; 
 &lt;BR&gt; 
**Jupiter Pharmacy was converted from a partnership firm into Jupiter Hospital Pharmacy Private Limited on March 2, 2025. Following the receipt of operating and statutory licenses for its various locations, the entity has been consolidated line-by-line from respective dates. &lt;BR&gt; 
 &lt;BR&gt; 
4. The Group is primarily engaged in the business of Healthcare services in India, which constitutes its only reportable business and geographical segment in accordance with Ind AS 108 - Operating Segments. Accordingly, no separate segment disclosures are required. Further, segment reporting for its Hotel division is not required, as its contribution to the Group’s total revenue, profit, and assets is below the 10% thresholds specified under Ind AS 108. &lt;BR&gt; 
 &lt;BR&gt; 
5. The figures for the quarter ended March 31, 2025, are the balancing figures between audited consolidated figures in respect of the full financial year and the unaudited published year-to-date figures for the nine months ended December 31, 2024. &lt;BR&gt; 
 &lt;BR&gt; 
6. Previous period figures have been regrouped and/or reclassified to conform to the current period presentation, wherever necessary. &lt;BR&gt; 
 &lt;BR&gt; 
7. The unaudited consolidated financial results are available on the Company’s website (www.jupiterhospital.com) and on the websites of the Stock Exchanges (www.bseindia.com and www.nseindia.com).</in-capmkt:DisclosureOfNotesOnFinancialResultsExplanatoryTextBlock><in-capmkt:DescriptionOfOtherExpenses contextRef="OneExpenses1D">Professional fees</in-capmkt:DescriptionOfOtherExpenses><in-capmkt:OtherExpenses contextRef="OneExpenses1D" decimals="-4" unitRef="INR">827360000</in-capmkt:OtherExpenses><in-capmkt:DescriptionOfOtherExpenses contextRef="OneExpenses2D">Other expenses</in-capmkt:DescriptionOfOtherExpenses><in-capmkt:OtherExpenses contextRef="OneExpenses2D" decimals="-4" unitRef="INR">589670000</in-capmkt:OtherExpenses></xbrli:xbrl>