<?xml version="1.0" encoding="UTF-8" standalone="no"?><!--IFFIndAs--><xbrli:xbrl xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-01-31/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/IntegratedFinance_IndAS/2025-01-31/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="http://www.sebi.gov.in/xbrl/IntegratedFinance_IndAS/2025-01-31/in-capmkt-roles" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2025-01-31/in-capmkt-types" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:xlink="http://www.w3.org/1999/xlink"><link:schemaRef 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 &lt;BR&gt; 
Notes to the Statement of Standalone Financial Results for quarter ended 30 June 2025                              All amounts in INR millions  except share data and where otherwise stated  &lt;BR&gt; 
1  The above Standalone Financial Results of the Indegene Limited the Company have been prepared in accordance with Indian Accounting Standards   Ind AS  34  Interim Financial Reporting  recognition and measurement principles of Indian Accounting Standards   Ind AS   prescribed under Section 133 of the Companies Act  2013  as amended  read with the relevant rules issued there under and in terms of Regulation 33 of the SEBI  Listing Obligations and Disclosure Requirements  Regulations  2015   the Regulations    Due to rounding off  the numbers presented throughout may not add up precisely to the totals  The symbol caret in the financial information denote amounts less than INR 5 lakhs &lt;BR&gt; 
2  The above Standalone Financial Results have been reviewed by the Audit Committee meeting held on 29 July 2025 and approved by the Board of Directors at its meeting held on 31 July 2025  The statutory auditors have performed a limited review of the Standalone Financial Results for the quarter ended 30 June 2025 and have issued an unmodified review report on the same &lt;BR&gt; 
3  The Standalone Financial Results include the results for the quarter ended 31 March 2025 being the balancing figures between audited figures in respect of full financial year up to 31 March 2025 and the unaudited published year to date figures up to 31 December 2024 being the date of the end of the third quarter of the financial year which were subjected to a limited review &lt;BR&gt; 
4  The Standalone Financial Results for the quarter ended 30 June 2025 are available on the National Stock Exchange of India Limited URL www nseindia com the BSE Limited website URL www bseindia com and on the Company s website URL www indegene com investor relations &lt;BR&gt; 
5  The Company publishes this Standalone Financial Results along with the Consolidated Financial Results In accordance with Ind AS 108 Operating Segments the Company has disclosed the segment information in the Consolidated Financial Results &lt;BR&gt; 
6  Final dividend for the financial year 2024 25 of INR 2 per share was approved by the shareholders at the 27th Annual General Meeting held on 26 June 2025 and the same was paid on 30 June 2025</in-capmkt:DisclosureOfNotesOnFinancialResultsExplanatoryTextBlock><in-capmkt:DescriptionOfOtherExpenses contextRef="OneExpenses1D">Other expenses</in-capmkt:DescriptionOfOtherExpenses><in-capmkt:OtherExpenses contextRef="OneExpenses1D" decimals="-6" unitRef="INR">373000000</in-capmkt:OtherExpenses><in-capmkt:DescriptionOfItemThatWillNotBeReclassifiedToProfitAndLoss contextRef="D_ItemsThatWillNotBeReclassifiedToProfitAndLoss11">Remeasurement of defined benefit obligation</in-capmkt:DescriptionOfItemThatWillNotBeReclassifiedToProfitAndLoss><in-capmkt:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss contextRef="D_ItemsThatWillNotBeReclassifiedToProfitAndLoss11" decimals="-6" unitRef="INR">12000000</in-capmkt:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss><in-capmkt:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss contextRef="OneD" decimals="-6" unitRef="INR">12000000</in-capmkt:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss><in-capmkt:IncomeTaxRelatingToItemsThatWillNotBeReclassifiedToProfitOrLoss contextRef="OneD" decimals="-6" unitRef="INR">3000000</in-capmkt:IncomeTaxRelatingToItemsThatWillNotBeReclassifiedToProfitOrLoss><in-capmkt:IncomeTaxRelatingToItemsThatWillBeReclassifiedToProfitOrLoss contextRef="OneD" decimals="-6" unitRef="INR">0</in-capmkt:IncomeTaxRelatingToItemsThatWillBeReclassifiedToProfitOrLoss><in-capmkt:OtherComprehensiveIncome contextRef="OneD" decimals="-6" unitRef="INR">9000000</in-capmkt:OtherComprehensiveIncome><in-capmkt:WhetherResultsAreAuditedOrUnauditedForImpactOfAuditQualification contextRef="OneD">Unaudited</in-capmkt:WhetherResultsAreAuditedOrUnauditedForImpactOfAuditQualification><in-capmkt:DeclarationPursuantToClauseDOfSubRegulation3OfRegulation33OfSEBILODRRegulation2015 contextRef="OneD">true</in-capmkt:DeclarationPursuantToClauseDOfSubRegulation3OfRegulation33OfSEBILODRRegulation2015><in-capmkt:AuditorsFirmName contextRef="D_Auditor1">Deloitte Haskins &amp; Sells</in-capmkt:AuditorsFirmName><in-capmkt:WhetherTheFirmHoldsAValidPeerReviewCertificateIssuedByPeerReviewBoardOfICAI contextRef="D_Auditor1">true</in-capmkt:WhetherTheFirmHoldsAValidPeerReviewCertificateIssuedByPeerReviewBoardOfICAI><in-capmkt:ValidityDateOfCertificate contextRef="D_Auditor1">2028-04-30</in-capmkt:ValidityDateOfCertificate></xbrli:xbrl>