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<xbrli:xbrl xmlns:in-bse-fin="http://www.bseindia.com/xbrl/fin/2020-03-31/in-bse-fin" xmlns:in-bse-fin-roles="http://www.bseindia.com/xbrl/fin/2020-03-31/in-bse-fin-roles" xmlns:in-bse-fin-ent="http://www.bseindia.com/xbrl/fin/2020-03-31/in-bse-fin/in-bse-fin-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-bse-fin-types="http://www.bseindia.com/xbrl/fin/2020-03-31/in-bse-fin-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="Ind-AS_entry_point_2020-03-31.xsd"/><xbrli:context id="OneD"><xbrli:entity><xbrli:identifier scheme="http://www.bseindia.com/bse-fin/NSESymbol">SAKAR</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2022-04-01</xbrli:startDate><xbrli:endDate>2022-06-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="OneExpenses1D"><xbrli:entity><xbrli:identifier scheme="http://www.bseindia.com/bse-fin/NSESymbol">SAKAR</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2022-04-01</xbrli:startDate><xbrli:endDate>2022-06-30</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:explicitMember dimension="in-bse-fin:DetailsOfOtherExpensesAxis">in-bse-fin:OtherExpenses1Member</xbrldi:explicitMember></xbrli:scenario></xbrli:context><xbrli:context id="D_ItemsThatWillNotBeReclassifiedToProfitAndLoss11"><xbrli:entity><xbrli:identifier scheme="http://www.bseindia.com/bse-fin/NSESymbol">SAKAR</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2022-04-01</xbrli:startDate><xbrli:endDate>2022-06-30</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-bse-fin:ItemsThatWillNotBeReclassifiedToProfitAndLossAxis"><in-bse-fin:ItemsThatWillNotBeReclassifiedToProfitAndLossDomain>ItemsThatWillNotBeReclassifiedToProfitAndLoss1</in-bse-fin:ItemsThatWillNotBeReclassifiedToProfitAndLossDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:unit id="INR"><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unit><xbrli:unit id="INRPerShare"><xbrli:divide><xbrli:unitNumerator><xbrli:measure>iso4217:INR</xbrli:measure></xbrli:unitNumerator><xbrli:unitDenominator><xbrli:measure>xbrli:shares</xbrli:measure></xbrli:unitDenominator></xbrli:divide></xbrli:unit><in-bse-fin:Symbol contextRef="OneD">SAKAR</in-bse-fin:Symbol><in-bse-fin:ISIN contextRef="OneD">INE732S01012</in-bse-fin:ISIN><in-bse-fin:NameOfTheCompany contextRef="OneD">SAKAR HEALTHCARE LIMITED</in-bse-fin:NameOfTheCompany><in-bse-fin:ClassOfSecurity contextRef="OneD">Equity</in-bse-fin:ClassOfSecurity><in-bse-fin:DateOfStartOfFinancialYear contextRef="OneD">2022-04-01</in-bse-fin:DateOfStartOfFinancialYear><in-bse-fin:DateOfEndOfFinancialYear contextRef="OneD">2023-03-31</in-bse-fin:DateOfEndOfFinancialYear><in-bse-fin:DateOfBoardMeetingWhenFinancialResultsWereApproved contextRef="OneD">2022-08-06</in-bse-fin:DateOfBoardMeetingWhenFinancialResultsWereApproved><in-bse-fin:DateOnWhichPriorIntimationOfTheMeetingForConsideringFinancialResultsWasInformedToTheExchange contextRef="OneD">2022-07-27</in-bse-fin:DateOnWhichPriorIntimationOfTheMeetingForConsideringFinancialResultsWasInformedToTheExchange><in-bse-fin:DescriptionOfPresentationCurrency contextRef="OneD">INR</in-bse-fin:DescriptionOfPresentationCurrency><in-bse-fin:LevelOfRoundingUsedInFinancialStatements contextRef="OneD">Lakhs</in-bse-fin:LevelOfRoundingUsedInFinancialStatements><in-bse-fin:ReportingQuarter contextRef="OneD">First quarter</in-bse-fin:ReportingQuarter><in-bse-fin:IsCompanyReportingMultisegmentOrSingleSegment contextRef="OneD">Single segment</in-bse-fin:IsCompanyReportingMultisegmentOrSingleSegment><in-bse-fin:DescriptionOfSingleSegment contextRef="OneD">Pharmaceuticals</in-bse-fin:DescriptionOfSingleSegment><in-bse-fin:DateOfStartOfBoardMeeting contextRef="OneD">2022-08-06</in-bse-fin:DateOfStartOfBoardMeeting><in-bse-fin:StartTimeOfBoardMeeting contextRef="OneD">11:00:00</in-bse-fin:StartTimeOfBoardMeeting><in-bse-fin:DateOfEndOfBoardMeeting contextRef="OneD">2022-08-06</in-bse-fin:DateOfEndOfBoardMeeting><in-bse-fin:EndTimeOfBoardMeeting contextRef="OneD">11:45:00</in-bse-fin:EndTimeOfBoardMeeting><in-bse-fin:DeclarationOfUnmodifiedOpinionOrStatementOnImpactOfAuditQualification contextRef="OneD">Not applicable</in-bse-fin:DeclarationOfUnmodifiedOpinionOrStatementOnImpactOfAuditQualification><in-bse-fin:DateOfStartOfReportingPeriod contextRef="OneD">2022-04-01</in-bse-fin:DateOfStartOfReportingPeriod><in-bse-fin:DateOfEndOfReportingPeriod contextRef="OneD">2022-06-30</in-bse-fin:DateOfEndOfReportingPeriod><in-bse-fin:WhetherResultsAreAuditedOrUnaudited contextRef="OneD">Unaudited</in-bse-fin:WhetherResultsAreAuditedOrUnaudited><in-bse-fin:NatureOfReportStandaloneConsolidated contextRef="OneD">Standalone</in-bse-fin:NatureOfReportStandaloneConsolidated><in-bse-fin:RevenueFromOperations contextRef="OneD" unitRef="INR" decimals="-3">285339000</in-bse-fin:RevenueFromOperations><in-bse-fin:OtherIncome contextRef="OneD" unitRef="INR" decimals="-3">4079000</in-bse-fin:OtherIncome><in-bse-fin:Income contextRef="OneD" unitRef="INR" decimals="-3">289418000</in-bse-fin:Income><in-bse-fin:CostOfMaterialsConsumed contextRef="OneD" unitRef="INR" decimals="-3">164519000</in-bse-fin:CostOfMaterialsConsumed><in-bse-fin:PurchasesOfStockInTrade contextRef="OneD" unitRef="INR" decimals="-5">0</in-bse-fin:PurchasesOfStockInTrade><in-bse-fin:ChangesInInventoriesOfFinishedGoodsWorkInProgressAndStockInTrade contextRef="OneD" unitRef="INR" decimals="-3">-5035000</in-bse-fin:ChangesInInventoriesOfFinishedGoodsWorkInProgressAndStockInTrade><in-bse-fin:EmployeeBenefitExpense contextRef="OneD" unitRef="INR" decimals="-3">32047000</in-bse-fin:EmployeeBenefitExpense><in-bse-fin:FinanceCosts contextRef="OneD" unitRef="INR" decimals="-3">8586000</in-bse-fin:FinanceCosts><in-bse-fin:DepreciationDepletionAndAmortisationExpense contextRef="OneD" unitRef="INR" decimals="-3">35691000</in-bse-fin:DepreciationDepletionAndAmortisationExpense><in-bse-fin:OtherExpenses contextRef="OneD" unitRef="INR" decimals="-4">14240000</in-bse-fin:OtherExpenses><in-bse-fin:Expenses contextRef="OneD" unitRef="INR" decimals="-3">250048000</in-bse-fin:Expenses><in-bse-fin:ProfitBeforeExceptionalItemsAndTax contextRef="OneD" unitRef="INR" decimals="-4">39370000</in-bse-fin:ProfitBeforeExceptionalItemsAndTax><in-bse-fin:ExceptionalItemsBeforeTax contextRef="OneD" unitRef="INR" decimals="-5">0</in-bse-fin:ExceptionalItemsBeforeTax><in-bse-fin:ProfitBeforeTax contextRef="OneD" unitRef="INR" decimals="-4">39370000</in-bse-fin:ProfitBeforeTax><in-bse-fin:CurrentTax contextRef="OneD" unitRef="INR" decimals="-5">0</in-bse-fin:CurrentTax><in-bse-fin:DeferredTax contextRef="OneD" unitRef="INR" decimals="-3">10585000</in-bse-fin:DeferredTax><in-bse-fin:TaxExpense contextRef="OneD" unitRef="INR" decimals="-3">10585000</in-bse-fin:TaxExpense><in-bse-fin:NetMovementInRegulatoryDeferralAccountBalancesRelatedToProfitOrLossAndTheRelatedDeferredTaxMovement contextRef="OneD" unitRef="INR" 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decimals="-5">0</in-bse-fin:ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod><in-bse-fin:ProfitLossForPeriod contextRef="OneD" unitRef="INR" decimals="-3">28785000</in-bse-fin:ProfitLossForPeriod><in-bse-fin:OtherComprehensiveIncomeNetOfTaxes contextRef="OneD" unitRef="INR" decimals="-3">-583000</in-bse-fin:OtherComprehensiveIncomeNetOfTaxes><in-bse-fin:ComprehensiveIncomeForThePeriod contextRef="OneD" unitRef="INR" decimals="-3">28202000</in-bse-fin:ComprehensiveIncomeForThePeriod><in-bse-fin:ComprehensiveIncomeForThePeriodAttributableToOwnersOfParent contextRef="OneD" unitRef="INR" decimals="-5">0</in-bse-fin:ComprehensiveIncomeForThePeriodAttributableToOwnersOfParent><in-bse-fin:ComprehensiveIncomeForThePeriodAttributableToOwnersOfParentNonControllingInterests contextRef="OneD" unitRef="INR" decimals="-5">0</in-bse-fin:ComprehensiveIncomeForThePeriodAttributableToOwnersOfParentNonControllingInterests><in-bse-fin:PaidUpValueOfEquityShareCapital contextRef="OneD" unitRef="INR" decimals="-4">171180000</in-bse-fin:PaidUpValueOfEquityShareCapital><in-bse-fin:FaceValueOfEquityShareCapital contextRef="OneD" unitRef="INRPerShare" decimals="INF">10</in-bse-fin:FaceValueOfEquityShareCapital><in-bse-fin:BasicEarningsLossPerShareFromContinuingOperations contextRef="OneD" unitRef="INRPerShare" decimals="INF">1.65</in-bse-fin:BasicEarningsLossPerShareFromContinuingOperations><in-bse-fin:DilutedEarningsLossPerShareFromContinuingOperations contextRef="OneD" unitRef="INRPerShare" decimals="INF">1.65</in-bse-fin:DilutedEarningsLossPerShareFromContinuingOperations><in-bse-fin:BasicEarningsLossPerShareFromDiscontinuedOperations contextRef="OneD" unitRef="INRPerShare" decimals="INF">0</in-bse-fin:BasicEarningsLossPerShareFromDiscontinuedOperations><in-bse-fin:DilutedEarningsLossPerShareFromDiscontinuedOperations contextRef="OneD" unitRef="INRPerShare" decimals="INF">0</in-bse-fin:DilutedEarningsLossPerShareFromDiscontinuedOperations><in-bse-fin:BasicEarningsLossPerShareFromContinuingAndDiscontinuedOperations contextRef="OneD" unitRef="INRPerShare" decimals="INF">1.65</in-bse-fin:BasicEarningsLossPerShareFromContinuingAndDiscontinuedOperations><in-bse-fin:DilutedEarningsLossPerShareFromContinuingAndDiscontinuedOperations contextRef="OneD" unitRef="INRPerShare" decimals="INF">1.65</in-bse-fin:DilutedEarningsLossPerShareFromContinuingAndDiscontinuedOperations><in-bse-fin:DisclosureOfNotesOnFinancialResultsExplanatoryTextBlock contextRef="OneD">&lt;div&gt; &lt;br&gt;&lt;/br&gt; 
&lt;div&gt; &lt;br&gt;&lt;/br&gt; 
&lt;table&gt; &lt;br&gt;&lt;/br&gt; 
&lt;tbody&gt; &lt;br&gt;&lt;/br&gt; 
&lt;tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;1&lt;/span&gt;&lt;/p&gt;&lt;/td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;The Company is operating only in one segment. Hence segment reporting is not given.&lt;/span&gt;&lt;/p&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;&lt;/td&gt;&lt;/tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;2&lt;/span&gt;&lt;/p&gt;&lt;/td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;The above financial results have been prepared in accordance with the Companies (Indian Accounting Standards) Rules, 2015 (Ind AS) as amended, prescribed under Section 133 of the Companies Act, 2013, read with relevant rules issued thereunder.&lt;/span&gt;&lt;/p&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;&lt;/td&gt;&lt;/tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;3&lt;/span&gt;&lt;/p&gt;&lt;/td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;The Company has a wholly owned subsidiary vis.&lt;span&gt;&amp;nbsp; &lt;/span&gt;M/s. Sakar Oncology Private Limited. Other than this, the Company does not have any subsidiary/ associate. &lt;/span&gt;&lt;/p&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;&lt;/td&gt;&lt;/tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;4&lt;/span&gt;&lt;/p&gt;&lt;/td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;Provision for taxation/deferred taxation, if any, will be made at the year end.&lt;/span&gt;&lt;/p&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;&lt;/td&gt;&lt;/tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;5&lt;/span&gt;&lt;/p&gt;&lt;/td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;Figures, wherever required, are regrouped / rearranged. &lt;/span&gt;&lt;/p&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;&lt;/td&gt;&lt;/tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;tr&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;6&lt;/span&gt;&lt;/p&gt;&lt;/td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;td&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;The above results have been reviewed by audit committee and approved by Board of Directors of Company at its meeting held on 6th August, 2022&lt;/span&gt;&lt;/p&gt; &lt;br&gt;&lt;/br&gt; 
&lt;p&gt;&lt;span&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/tbody&gt;&lt;/table&gt;&lt;/div&gt;&lt;/div&gt;</in-bse-fin:DisclosureOfNotesOnFinancialResultsExplanatoryTextBlock><in-bse-fin:DescriptionOfOtherExpenses contextRef="OneExpenses1D">Other Expenses</in-bse-fin:DescriptionOfOtherExpenses><in-bse-fin:OtherExpenses contextRef="OneExpenses1D" unitRef="INR" decimals="-4">14240000</in-bse-fin:OtherExpenses><in-bse-fin:DescriptionOfItemThatWillNotBeReclassifiedToProfitAndLoss contextRef="D_ItemsThatWillNotBeReclassifiedToProfitAndLoss11">Re-measurement gains (losses) on defined benefit plans</in-bse-fin:DescriptionOfItemThatWillNotBeReclassifiedToProfitAndLoss><in-bse-fin:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss contextRef="D_ItemsThatWillNotBeReclassifiedToProfitAndLoss11" unitRef="INR" decimals="-3">-808000</in-bse-fin:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss><in-bse-fin:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss contextRef="OneD" unitRef="INR" decimals="-3">-808000</in-bse-fin:AmountOfItemThatWillNotBeReclassifiedToProfitAndLoss><in-bse-fin:IncomeTaxRelatingToItmesThatWillNotBeReclassifiedToProfitOrLoss contextRef="OneD" unitRef="INR" decimals="-3">-225000</in-bse-fin:IncomeTaxRelatingToItmesThatWillNotBeReclassifiedToProfitOrLoss><in-bse-fin:IncomeTaxRelatingToItmesThatWillBeReclassifiedToProfitOrLoss contextRef="OneD" unitRef="INR" decimals="-5">0</in-bse-fin:IncomeTaxRelatingToItmesThatWillBeReclassifiedToProfitOrLoss></xbrli:xbrl>
