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<xbrli:xbrl xmlns:in-capmkt="http://www.sebi.gov.in/xbrl/2025-11-30/in-capmkt" xmlns:in-capmkt-ent="http://www.sebi.gov.in/xbrl/Changes_In_Management/2025-11-30/in-capmkt/in-capmkt-ent" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-types="http://www.sebi.gov.in/xbrl/2025-11-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.w3.org/1999/xlink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2025-11-30.xsd"/><xbrli:context id="MainD"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/NSESymbol">SHILPAMED</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-04-23</xbrli:startDate><xbrli:endDate>2026-04-23</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/NSESymbol">SHILPAMED</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-04-23</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="I_ChangeInManagement1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/NSESymbol">SHILPAMED</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-04-23</xbrli:instant></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ChangeInManagementAxis"><in-capmkt:ChangeInManagementDomain>ChangeInManagementDomain1</in-capmkt:ChangeInManagementDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:context id="D_ChangeInManagement1"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/NSESymbol">SHILPAMED</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-04-23</xbrli:startDate><xbrli:endDate>2026-04-23</xbrli:endDate></xbrli:period><xbrli:scenario><xbrldi:typedMember dimension="in-capmkt:ChangeInManagementAxis"><in-capmkt:ChangeInManagementDomain>ChangeInManagementDomain1</in-capmkt:ChangeInManagementDomain></xbrldi:typedMember></xbrli:scenario></xbrli:context><xbrli:unit id="pure"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><in-capmkt:NSESymbol contextRef="MainI">SHILPAMED</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">SHILPA MEDICARE LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:ScripCode contextRef="MainI">530549</in-capmkt:ScripCode><in-capmkt:MSEISymbol contextRef="MainI">NOTLISTED</in-capmkt:MSEISymbol><in-capmkt:ISIN contextRef="MainI">INE790G01031</in-capmkt:ISIN><in-capmkt:WhetherDisclosureFiledForListedEntity contextRef="MainD">true</in-capmkt:WhetherDisclosureFiledForListedEntity><in-capmkt:RelationshipWithTheListedEntity contextRef="MainD">Listed Entity (self)</in-capmkt:RelationshipWithTheListedEntity><in-capmkt:WhetherEventOrInformationIsAnOutcomeOfBoardMeeting contextRef="MainD">false</in-capmkt:WhetherEventOrInformationIsAnOutcomeOfBoardMeeting><in-capmkt:DateOfOccurrenceOfEventOrInformation contextRef="MainD">2026-04-22</in-capmkt:DateOfOccurrenceOfEventOrInformation><in-capmkt:TimeOfOccurrenceOfEventOrInformation contextRef="MainD">08:50:00</in-capmkt:TimeOfOccurrenceOfEventOrInformation><in-capmkt:NumberOfPersonsOrEntitiesForWhomChangeIsBeingReported contextRef="MainI" unitRef="pure" decimals="0">1</in-capmkt:NumberOfPersonsOrEntitiesForWhomChangeIsBeingReported><in-capmkt:DateOfReport contextRef="MainI">2026-04-23</in-capmkt:DateOfReport><in-capmkt:TypeOfChange contextRef="D_ChangeInManagement1">Appointment</in-capmkt:TypeOfChange><in-capmkt:CategoryForChange contextRef="D_ChangeInManagement1">Senior Management Personnel</in-capmkt:CategoryForChange><in-capmkt:DesignationOfDesignatedPerson contextRef="D_ChangeInManagement1">COO</in-capmkt:DesignationOfDesignatedPerson><in-capmkt:SalutationOfDesignatedPerson contextRef="D_ChangeInManagement1">Mr.</in-capmkt:SalutationOfDesignatedPerson><in-capmkt:NameOfDesignatedPerson contextRef="I_ChangeInManagement1">Vellaian Karuppiah</in-capmkt:NameOfDesignatedPerson><in-capmkt:EffectiveDateOfReasonOfChange contextRef="I_ChangeInManagement1">2026-04-23</in-capmkt:EffectiveDateOfReasonOfChange><in-capmkt:BriefProfile contextRef="D_ChangeInManagement1">Dr. Vellaian Karuppiah aged 52 years, brings over 33 years of extensive and diverse experience across the pharmaceutical value chain with deep expertise spanning Formulation &amp; Analytical R&amp;D, Regulatory Affairs, Manufacturing Science &amp; Technology (MS&amp;T), Technology Transfer, Engineering &amp; Projects, Quality Systems, EHS/ESG, Supply Chain Management, PPIC, and end-to-end Manufacturing Operations.
He has held senior leadership and C-suite positions in several globally reputed pharmaceutical organizations including Gland Pharma Limited (Fosun Group), Strides Group, Dr. Reddy’s Laboratories, Actavis (now Teva), Orchid Healthcare (Hospira/Pfizer), amongst few others.
His career reflects strong global exposure and cross-functional leadership, with a consistent track record in driving operational excellence, regulatory compliance, and business transformation initiatives. In his recent roles as Chief Operating Officer at Acme Group and Immacule Lifesciences, Dr. Karuppiah has been instrumental in strengthening manufacturing efficiency, supply chain resilience, quality systems, and R&amp;D integration, thereby contributing significantly to organizational growth and competitiveness. Dr. Vellaian Karuppiah holds a Postgraduate degree and Doctorate in Pharmacy, along with Executive Management qualifications from premier Tier-1 institutions in India and abroad. Given his proven leadership capabilities, strategic orientation, and rich industry experience, his appointment is expected to significantly strengthen the Company’s Formulation business operations, enhance operational efficiencies, and support long-term sustainable growth.</in-capmkt:BriefProfile></xbrli:xbrl>
