<?xml version="1.0" encoding="UTF-8"?>
<!--ANNAgreement V1.0 (10-04-2026)-->
<xbrli:xbrl xmlns:in-capmkt="https://www.sebi.gov.in/xbrl/2024-04-30/in-capmkt" xmlns:in-capmkt-ent="https://www.sebi.gov.in/xbrl/Announcement_For_Agreements/2024-04-30/in-capmkt/in-capmkt-ent" xmlns:in-capmkt-roles="https://www.sebi.gov.in/xbrl/Announcement_For_Agreements/2024-04-30/in-capmkt-roles" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:in-capmkt-type="https://www.sebi.gov.in/xbrl/2024-04-30/in-capmkt-types" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xl="http://www.xbrl.org/2003/XLink"><link:schemaRef xlink:type="simple" xlink:href="in-capmkt-ent-2024-04-30.xsd"/><xbrli:context id="MainD"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/NSESymbol">NEPHROCARE</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2026-09-10</xbrli:startDate><xbrli:endDate>2026-09-10</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="MainI"><xbrli:entity><xbrli:identifier scheme="https://www.sebi.gov.in/in-capmkt/NSESymbol">NEPHROCARE</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2026-09-10</xbrli:instant></xbrli:period></xbrli:context><in-capmkt:NSESymbol contextRef="MainI">NEPHROCARE</in-capmkt:NSESymbol><in-capmkt:NameOfTheCompany contextRef="MainI">NEPHRO CARE INDIA LIMITED</in-capmkt:NameOfTheCompany><in-capmkt:TypeOfAnnouncement contextRef="MainI">New</in-capmkt:TypeOfAnnouncement><in-capmkt:TypeOfAgreement contextRef="MainI">Others</in-capmkt:TypeOfAgreement><in-capmkt:DetailsOfOtherTypeOfAnnouncement contextRef="MainI">Discontinuation of DAD Unit Operations</in-capmkt:DetailsOfOtherTypeOfAnnouncement><in-capmkt:StageOfAgreement contextRef="MainI">Termination of agreement</in-capmkt:StageOfAgreement><in-capmkt:AgreementsEnteredIntoBy contextRef="MainD">Listed Entity</in-capmkt:AgreementsEnteredIntoBy><in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting contextRef="MainD">false</in-capmkt:WhetherEventOrInformationDisclosedIsAnOutcomeOfBoardMeeting><in-capmkt:DateOfOccurrenceOfEvent contextRef="MainI">2026-09-15</in-capmkt:DateOfOccurrenceOfEvent><in-capmkt:TimeOfOccurrenceOfEvent contextRef="MainD">00:00:00</in-capmkt:TimeOfOccurrenceOfEvent><in-capmkt:WhetherTheListedEntityIsPartyToTheAgreement contextRef="MainD">true</in-capmkt:WhetherTheListedEntityIsPartyToTheAgreement><in-capmkt:DateOfReport contextRef="MainI">2026-09-10</in-capmkt:DateOfReport><in-capmkt:DateOfInitialDisclosureOfTheExecutionOfTheAgreementToTheStockExchange contextRef="MainI">2024-04-09</in-capmkt:DateOfInitialDisclosureOfTheExecutionOfTheAgreementToTheStockExchange><in-capmkt:BriefDetailsOfTerminationOfAgreement contextRef="MainI">Due to regulatory and licensing constraints and non-availability of the requisite statutory licences/permissions.</in-capmkt:BriefDetailsOfTerminationOfAgreement><in-capmkt:NamesOfPartiesWithWhomTheAgreementWasEntered contextRef="MainI">E-AGE HEALTHCARE PRIVATE LIMITED</in-capmkt:NamesOfPartiesWithWhomTheAgreementWasEntered><in-capmkt:NatureOfTheAgreementForTerminationOfAgreement contextRef="MainI">MEMORANDUM OF UNDERSTANDING</in-capmkt:NatureOfTheAgreementForTerminationOfAgreement><in-capmkt:DateOfExecutionOfTheAgreement contextRef="MainI">2023-06-21</in-capmkt:DateOfExecutionOfTheAgreement><in-capmkt:ReasonForTerminatingTheAgreement contextRef="MainI">Due to regulatory and licensing constraints and non-availability of the requisite statutory licences/permissions.</in-capmkt:ReasonForTerminatingTheAgreement><in-capmkt:DetailsOfImpactOfTerminationOfTheAgreement contextRef="MainI">Discontinue of the DAD ("Dial a Dialysis) unit operation</in-capmkt:DetailsOfImpactOfTerminationOfTheAgreement></xbrli:xbrl>
